173064-91-0

Basic information

• Product Name: 5H-Cyclopenta[b]pyridin-5-one,6,7-dihydro-2-methyl-(9CI)
• Synonyms: 5H-Cyclopenta[b]pyridin-5-one,6,7-dihydro-2-methyl-(9CI)
• CAS NO: 173064-91-0
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17386
• Product Categories: PYRIDINE
• Mol File: 173064-91-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5H-Cyclopenta[b]pyridin-5-one,6,7-dihydro-2-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Cyclopenta[b]pyridin-5-one,6,7-dihydro-2-methyl-(9CI)(173064-91-0)
• EPA Substance Registry System: 5H-Cyclopenta[b]pyridin-5-one,6,7-dihydro-2-methyl-(9CI)(173064-91-0)

Safety Data

• Hazardous Substances Data: 173064-91-0(Hazardous Substances Data)

Upstream product

• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 28566-12-3 3-amino-cyclopent-2-en-1-one 
• 3859-41-4 1,3-cyclopentadione 
• 78-94-4 methyl vinyl ketone 
• 885277-48-5 methyl 2-bromo-6-methylpyridine-3-carboxylate 
• 38116-61-9 2-hydroxy-6-methylnicotinic acid 
• 853179-76-7 methyl 2-((E)-2-(methoxycarbonyl)vinyl)-6-methylpiridine-3-carboxylate 
• 853179-88-1 methyl 2-(2-(methoxycarbonyl)ethyl)-6-methylpyridine-3-carboxylate 

Relevant articles and documents

PROTEIN TYROSINE PHOSPHATASE INHIBITORS

Compounds of Formula la or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases in the view of their ability to inhibit SHP2. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

GHRELIN O-ACYLTRANSFERASE INHIBITORS

This invention relates to novel compounds according to Formula (I) which are inhibitors of ghrelin O-acyltransferase (GOAT), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment

Efficient and fast Heck vinylation of 2-bromo-6-methyl pyridines with methylacrylate. Application to the synthesis of 6-methyl cyclopenta[b]pyridinone

Heck vinylation of 2-bromo-6-methyl-3-substituted pyridines using η3-allylpalladium chloride dimer/P(o-Tol)3 complex/toluene and dimethylacetamide (DMA) as co-solvent with methyl acrylate is reported. Electronic and steric effects were investigated engaging diversely 2-bromo-3,6-disubstituted pyridines. As application, a new synthesis of the 6-methyl cyclopenta[b]pyridinone building-block connecting Heck vinylation, alkene reduction and Dieckmann condensation is described.