173099-59-7

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 173099-58-6 2'-N-phthalimido-2'-deoxyuridine 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 174221-86-4 5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine 
• 3083-77-0 araU 
• 169514-34-5 Trifluoro-methanesulfonic acid (2R,3S,3aR,9aR)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester 
• 401812-90-6 2-[(2R,3R,3aS,9aR)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl]-isoindole-1,3-dione 
• 104477-70-5 5',3'-O-(tetraisopropyldisiloxane-1,3-di-yl)-1-β-D-arabinofuranosyl-uracil 

Downstream Products

• 60966-26-9 2'-amino-2'-deoxyguanosine 
• 874443-90-0 5'-O-(4,4'-dimethoxytrityl)-N²-palmitoyl-2'-phthalimido-2'-deoxyguanosine 

Relevant academic research and scientific papers

Improved synthesis of 2′-amino-2′-deoxyguanosine and its phosphoramidite

2′-Amino-2′-deoxynucleosides and oligonucleotides containing them have proven highly effective for an array of biochemical applications. The guanosine analogue and its phosphoramidite derivatives have been accessed previously from 2′-amino-2′-deoxyuridine

Scaleable and efficient synthesis of 2'-deoxy-2'-N-phthaloyl nucleoside phosphoramidites for oligonucleotide synthesis.

2'-Deoxy-2'-N-phthaloyl nucleosides were prepared from arabino nucleosides by triflate displacement with phthalimide in the presence of DBU. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis were also synthesized. The scalability of described procedures was demonstrated on a 100-g scale preparation of 2'-deoxy-2'-amino-C phosphoramidite.