60966-26-9 Usage
Uses
Used in Biochemical Research:
2'-Amino-2'-deoxyguanosine is used as a valuable probe for investigating metal ion interactions at the active site of the group I ribozyme. This application is crucial for understanding the role of metal ions in the catalytic activity of ribozymes and their potential involvement in various biological processes.
Used in Pharmaceutical Industry:
2'-Amino-2'-deoxyguanosine is used as a key intermediate in the synthesis of antiviral and anticancer drugs. Its unique structure allows for the development of novel therapeutic agents that can target specific viral or cancer-related pathways, leading to more effective treatments with fewer side effects.
Used in Chemical Synthesis:
2'-Amino-2'-deoxyguanosine is used as a building block in the synthesis of various nucleic acid analogs and modified oligonucleotides. These modified nucleic acids can be employed in the development of new drugs, diagnostic tools, and therapeutic agents, as well as in the study of nucleic acid structure and function.
Used in Nanotechnology:
2'-Amino-2'-deoxyguanosine can be used in the development of nanomaterials and nanodevices for various applications, such as drug delivery, biosensors, and molecular electronics. Its unique chemical properties and ability to interact with metal ions make it a promising candidate for the design and fabrication of novel nanostructures.
Check Digit Verification of cas no
The CAS Registry Mumber 60966-26-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,9,6 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 60966-26:
(7*6)+(6*0)+(5*9)+(4*6)+(3*6)+(2*2)+(1*6)=139
139 % 10 = 9
So 60966-26-9 is a valid CAS Registry Number.
60966-26-9Relevant academic research and scientific papers
Improved synthesis of 2′-amino-2′-deoxyguanosine and its phosphoramidite
Dai, Qing,Deb, Shirshendu K.,Hougland, James L.,Piccirilli, Joseph A.
, p. 705 - 713 (2007/10/03)
2′-Amino-2′-deoxynucleosides and oligonucleotides containing them have proven highly effective for an array of biochemical applications. The guanosine analogue and its phosphoramidite derivatives have been accessed previously from 2′-amino-2′-deoxyuridine
Microbial Synthesis of Purine 2'-Amino-2'-deoxyribosides
Utagawa, Takashi,Mirisawa, Hirokazu,Yamanaka, Shigeru,Yamazaki, Akihiro,Hirose, Yoshio
, p. 2711 - 2718 (2007/10/02)
The microbial synthesis of some purine 2'-amino-2'-deoxyribonucleosides from purine bases and 2'-amino-2'-deoxyuridine is described.Various bacteria, especially Erwinia herbicola, Salmonella schottmuelleri, Enterobacter aerogenes and Escherichia coli, were able to transfer the aminoribosyl moiety of 2'-amino-2'-deoxyuridine to purine bases (transaminoribosylation) in the presence of inorganic phosphate.The optimum conditions for the reaction were pH 7.0 and 63 deg C.No reaction was observed in the abscence of inorganioc phosphate and the optimum concentration of it was around 30 mM.Adenine, guanine, 2-chlorohypoxanthine and hypoxanthine were transformed to the corresponding 2'-amino-2'-deoxyribonucleosides by the catalytic activity of the wet cell paste of Enterobacter aerogenes AJ 11125.The enzymatically synthesized purine 2'-amino-2'-deoyxyribonucleosides were isolated and identified by physicochemical means. 2'-Amino-2'-deoxyadenosine strongly inhibited the growth of Hela cells in theis tissue culture, and the ED50 was 2.5 μg/ml.
