17310-26-8

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Phenylhydrazono)-1H-indole-2-one is used as a medicinal compound for its anti-inflammatory and analgesic properties, providing potential relief for conditions characterized by inflammation and pain.
Used in Enzyme Inhibition Research:
In the field of medicinal chemistry, 3-(2-Phenylhydrazono)-1H-indole-2-one is used as an enzyme inhibitor, targeting specific enzymes implicated in various diseases. Its ability to inhibit these enzymes makes it a candidate for therapeutic intervention and a subject of ongoing research for potential treatments.
Used in Drug Development:
3-(2-Phenylhydrazono)-1H-indole-2-one is utilized in the development of new drugs, as its structural features and potential medicinal properties offer avenues for creating novel therapeutic agents. Ongoing research and development efforts aim to harness its potential for treating a range of diseases.

InChI:InChI=1/C14H11N3O/c18-14-13(11-8-4-5-9-12(11)15-14)17-16-10-6-2-1-3-7-10/h1-9,16H,(H,15,17,18)

Upstream product

• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 
• 100-63-0 phenylhydrazine 
• 14003-18-0 ethyl 2-(2-oxoindolin-3-ylidene)cyanoacetate 
• 62-53-3 aniline 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 77305-90-9 3-(phenylhydrazono)-1,3-dihydroindole-2-thione 
• 100460-69-3 dimethyl furo<2,3-b>indole-2,3-dicarboxylate 
• 100460-68-2 pyridazino<3,4-b>indole 
• 100460-70-6 methyl 3,4,5,6,7-pentamethoxycarbonyl-7-phenylhepta-2,4,6-trienoate 

Relevant academic research and scientific papers

Action of Hydrazines on 2-(2-Oxindolin-3-ylidene)malononitrile, (E,Z)-Ethyl 2-cyano-2-(2-oxindolin-3-ylidene)acetate and Isatin-β-thiosemicarbazone as a Source of Spiro Indoline-pyrazole Systems

2-(2-Oxindolin-3-ylidene)malononitrile (1a) or (E,Z)-ethyl 2-cyano-2-(2-oxindolin-3-ylidene)acetate (1b) or isatin-β-thiosemicarbazone (1c) undergoes reactions with prototype hydrazine hydrate itself and some of its simple congeners to give hydrazone derivatives bearing indoline-2-one moiety (2). The hydrazone derivatives (2) when heated with acetyl acetone or ethyl acetoacetate in dry pyridine afforded the spiro indoline derivatives (3a, 3b). Also, cinnoline derivative (9) is obtained by action of hydrazine hydrate on the N-acetyl derivative of (6a). The structures of the newly synthesized compounds were evaluated by IR, 1H-NMR spectroscopy, mass spectra and elemental analyses.

Synthesis, characterization and pharmacological screening of some isatinoid compounds

Schiff bases and hydrazones of substituted isatins have been prepared by reacting isatin and the appropriate aromatic primary amine l hydrazines and characterized by spectral and elementary analysis. The compounds have been screened for analgesic, antiinflammatory and antipyretic activity. 3[(4-Bromo phenylidene)-1-amino] isatin is the only compound to exhibit all the activities. 3[(4-Bromo phenylidene)-1-amino] isatin and 3[(4- Bromo phenylidene)-1-amino]-5-methyl isatin possesses analgesic activity equipotent to paracetamol. 3(4-Phenylhydrazino) isatin and 3(thiosemicarbazino) isatin exhibit marked reduction of acetic acid induced inflammation. 3[(4-Methyl phenylidene)-1-amino] isatin at 200 mg/kg exhibits pronounced antipyretic activity comparable to paracetamol.

Hydrazone derivatives and their use

A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization, comprising the step of administering to said subject an effective excitatory amino acid antagonizing amount of an indole-2,3-dione-3-h

Evaporator system comprising a stabilized pesticidal phosphoric acid ester and method for stabilizing such ester enclosed in an evaporator

An evaporator system adapted for emitting insect killing vapors of an insecticide therefrom and comprising a liquid or solid composition enclosed therein, said insecticide consisting in at least one volatile phosphoric acid ester which is stabilized by at least one diazene compound.