17310-26-8

Basic information

• Product Name: 3-(2-Phenylhydrazono)-1H-indole-2-one
• Synonyms: 3-(2-Phenylhydrazono)-1H-indole-2-one;Isatin phenyl hydrazone;3-(PHENYL-HYDRAZONO)-1,3-DIHYDRO-INDOL-2-ONE
• CAS NO: 17310-26-8
• Molecular Formula: C₁₄H₁₁N₃O
• Molecular Weight: 237.2566
• Mol File: 17310-26-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 363.2 °C at 760 mmHg
• Flash Point: 173.5 °C
• Appearance: /
• Density: 1.29 g/cm³
• Vapor Pressure: 1.83E-05mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: 3-(2-Phenylhydrazono)-1H-indole-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Phenylhydrazono)-1H-indole-2-one(17310-26-8)
• EPA Substance Registry System: 3-(2-Phenylhydrazono)-1H-indole-2-one(17310-26-8)

Safety Data

• Hazardous Substances Data: 17310-26-8(Hazardous Substances Data)

Usage

General Description

3-(2-Phenylhydrazono)-1H-indole-2-one, also known as oxindole hydrazone, is a chemical compound that combines the structural features of oxindole and hydrazones. It has been studied for its potential medicinal properties, including anti-inflammatory and analgesic effects. 3-(2-Phenylhydrazono)-1H-indole-2-one has also shown potential as an inhibitor of certain enzymes, making it of interest for potential therapeutic applications in the treatment of various diseases. The specific properties and potential uses of 3-(2-Phenylhydrazono)-1H-indole-2-one continue to be investigated, and it represents a promising avenue for future research and development in the field of medicinal chemistry.

InChI:InChI=1/C14H11N3O/c18-14-13(11-8-4-5-9-12(11)15-14)17-16-10-6-2-1-3-7-10/h1-9,16H,(H,15,17,18)

Upstream product

• 91-56-5 indole-2,3-dione 
• 100-63-0 phenylhydrazine 
• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 
• 14003-18-0 ethyl 2-(2-oxoindolin-3-ylidene)cyanoacetate 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 62-53-3 aniline 

Downstream Products

• 77305-90-9 3-(phenylhydrazono)-1,3-dihydroindole-2-thione 
• 100460-69-3 dimethyl furo<2,3-b>indole-2,3-dicarboxylate 
• 100460-68-2 pyridazino<3,4-b>indole 
• 100460-70-6 methyl 3,4,5,6,7-pentamethoxycarbonyl-7-phenylhepta-2,4,6-trienoate 

Relevant articles and documents

Action of Hydrazines on 2-(2-Oxindolin-3-ylidene)malononitrile, (E,Z)-Ethyl 2-cyano-2-(2-oxindolin-3-ylidene)acetate and Isatin-β-thiosemicarbazone as a Source of Spiro Indoline-pyrazole Systems

2-(2-Oxindolin-3-ylidene)malononitrile (1a) or (E,Z)-ethyl 2-cyano-2-(2-oxindolin-3-ylidene)acetate (1b) or isatin-β-thiosemicarbazone (1c) undergoes reactions with prototype hydrazine hydrate itself and some of its simple congeners to give hydrazone derivatives bearing indoline-2-one moiety (2). The hydrazone derivatives (2) when heated with acetyl acetone or ethyl acetoacetate in dry pyridine afforded the spiro indoline derivatives (3a, 3b). Also, cinnoline derivative (9) is obtained by action of hydrazine hydrate on the N-acetyl derivative of (6a). The structures of the newly synthesized compounds were evaluated by IR, 1H-NMR spectroscopy, mass spectra and elemental analyses.

Hydrazone derivatives and their use

A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization, comprising the step of administering to said subject an effective excitatory amino acid antagonizing amount of an indole-2,3-dione-3-h