17315-41-2

Upstream product

• 1066-44-0 trimethyltin bromide 
• 36229-42-2 (3-chlorophenyl)magnesium bromide 
• 108-37-2 1-bromo-3-chlorobenzene 
• 1066-45-1 trimethyltin(IV)chloride 

Downstream Products

• 93352-83-1 1-Chloro-3-<(4-methylphenyl)sulfonyl>benzene 
• 10286-92-7 3-Chloro-N-(3-chlorophenyl)benzamide 
• 932-78-5 1-chloro-3-nitrosobenzene 
• 1066-45-1 trimethyltin(IV)chloride 
• 67407-60-7 Pt(cyclo-octa-1,5-diene)(C₆H₄Cl-m)2 
• 2051-61-8 m-chlorobiphenyl 
• 68984-05-4 3-chlorobenzenesulfonyl isocyanate 

Relevant academic research and scientific papers

1,2,3,4-TETRAHYDRO-QUINOLINE DERIVATIVES AS CETP INHIBITORS

The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.

Synthesis of Aromatic and Olefinic Sodium Sulfonates by Electrophilic Destannylation with Trimethylsilyl Chlorosulfonate

A mild and effective method for the preparation of a variety of aromatic, olefinic, and acetylenic sodium sulfonates is described.The reaction of trialkylaryl- (2a-k) and -heteroarylstannanes (4a-d), bis-(1-alkenyl)dibutylstannanes (6a-f), or trialkylakynylstannanes with trimethylsilyl chlorosulfonate (1) followed by hydrolysis with aqueous NaHCO3 provides the sodium sulfonates in an ipso-specific and in the case of vinylic stannanes stereospecific manner.A comparision of the reactivity of stannylated and silylated olefinic compounds 13 and 14 underlines the greater leaving ability of the stannyl moiety.The in situ preparation of the stannanes makes it possible to apply the synthetic method to natural products such as N-substituted apocodeine (17). - Key Words: Electrophilic aromatic substitution/ Electrophilic vinylic substitution/ Trialkylstannanes, application of/ Arylsulfonates, sodium salts of/ Vinylsulfonates, sodium salts of