932-78-5

Basic information

• Product Name: Benzene, 1-chloro-3-nitroso-
• Synonyms: Benzene, 1-chloro-3-nitroso-
• CAS NO: 932-78-5
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.55506
• Mol File: 932-78-5.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzene, 1-chloro-3-nitroso-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-3-nitroso-(932-78-5)
• EPA Substance Registry System: Benzene, 1-chloro-3-nitroso-(932-78-5)

Safety Data

• Hazardous Substances Data: 932-78-5(Hazardous Substances Data)

Usage

General Description

Benzene, 1-chloro-3-nitroso- is a chemical compound with the molecular formula C6H5ClNO. It is a pale yellow liquid with a strong odor, and it is primarily used as an intermediate in the production of agricultural and pharmaceutical chemicals. Benzene, 1-chloro-3-nitroso- is also known to be a potential carcinogen and has been linked to adverse health effects in humans, including irritation of the skin, eyes, and respiratory tract. It is important to handle and use this chemical with caution and in accordance with safety regulations to minimize the risk of exposure and the potential for harm to human health and the environment.

Upstream product

• 10468-17-4 N-(3-chlorophenyl)hydroxylamine 
• 121-73-3 3-Nitrochlorobenzene 
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• 108-42-9 3-chloro-aniline 

Downstream Products

• 139-24-2 3,3'-dichloroazoxybenzene 
• 62858-14-4 (3-chloro-phenyl)-(4-nitro-phenyl)-diazene 
• 32116-99-7 (4-Chloro-3-nitro-phenyl)-(3-chloro-phenyl)-diazene 
• 96018-75-6 N-(3-Chloro-phenyl)-N-hydroxy-formamide 
• 10468-17-4 N-(3-chlorophenyl)hydroxylamine 
• 139-24-2 (Z)-1,2-bis(3-chlorophenyl)diazene 1-oxide 
• 2528-64-5 2.3'-Dichlor-azobenzol 
• 2528-66-7 3,3',5-Trichlor-azobenzol 
• 946-31-6 2-chloro-4,6-dinitro-phenol 
• 2528-78-1 4.4'-Di-(4-heptyloxy-benzylidenamino)-2.3'-dichlor-biphenyl 
• 2634-42-6 4.4'-Di-(4-octyloxy-benzylidenamino)-2.3'-dichlor-biphenyl 
• 2401-34-5 4.4'-Di-(4-heptyloxy-benzylidenamino)-2.2'.6-trichlor-biphenyl 
• 2528-76-9 4.4'-Di-(4-nonyloxy-benzylidenamino)-2.3'-dichlor-biphenyl 
• 2528-77-0 4.4'-Di-(4-decyloxy-benzylidenamino)-2.3'-dichlor-biphenyl 

Relevant articles and documents

Transketolase Catalyzed Synthesis of N-Aryl Hydroxamic Acids

Hydroxamic acids are metal-chelating compounds that show important biological activity including anti-tumor effects. We have recently engineered the transketolase from Geobacillus stearothermopilus (TKgst) to convert benzaldehyde as a non-natur

Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation

Many (poly-)phenolic natural products, for example, curcumin and taxifolin, have been studied for their activity against specific hallmarks of neurodegeneration, such as amyloid-β 42 (Aβ42) aggregation and neuroinflammation. Due to their drawbacks, arising from poor pharmacokinetics, rapid metabolism, and even instability in aqueous medium, the biological activity of azobenzene compounds carrying a pharmacophoric catechol group, which have been designed as bioisoteres of curcumin has been examined. Molecular simulations reveal the ability of these compounds to form a hydrophobic cluster with Aβ42, which adopts different folds, affecting the propensity to populate fibril-like conformations. Furthermore, the curcumin bioisosteres exceeded the parent compound in activity against Aβ42 aggregation inhibition, glutamate-induced intracellular oxidative stress in HT22 cells, and neuroinflammation in microglial BV-2 cells. The most active compound prevented apoptosis of HT22 cells at a concentration of 2.5 μm (83 % cell survival), whereas curcumin only showed very low protection at 10 μm (21 % cell survival).

Rhodium-Catalyzed Reaction of Azobenzenes and Nitrosoarenes toward Phenazines

A rhodium-catalyzed annulative reaction between azobenzenes and nitrosoarenes has been developed, leading to a series of phenazines in moderate to good yields. This procedure proceeds with sequential chelation-assisted addition of aryl C-H to nitrosoarenes and ring closure by electrophilic attack of azo group to aryl. During this transformation, the azo group served as not only a traceless directing group but also a building block in the final products.