17321-62-9Relevant articles and documents
Overcoming steric effects in the coupling reaction of alkyloxycarbonyloxymethyl (AOCOM) halides with phenols: an efficient synthesis of AOCOM phenolic prodrugs
Thomas, Joshua D.,Sloan, Kenneth B.
, p. 109 - 112 (2007/10/03)
Steric hindrance is a key factor in the coupling reaction of AOCOM halides with phenols. Sterically unhindered alkoxy groups favor the formation of acylated phenol. Under phase-transfer conditions, alkylated phenol is favored regardless of steric hindrance.
Acetaminophen prodrugs. I. Synthesis, physicochemical properties, and analgesic activity.
Dittert,Caldwell,Adams,Irwin,Swintosky
, p. 774 - 780 (2007/10/05)
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