17321-97-0

Basic information

• Product Name: 2-Amino-4-methylpyrimidine-5-carbonitrile
• Synonyms: 2-AMINO-4-METHYL-PYRIMIDINE-5-CARBONITRILE;5-Pyrimidinecarbonitrile, 2-amino-4-methyl- (8CI,9CI)
• CAS NO: 17321-97-0
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.14
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 17321-97-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 269-270 °C
• Boiling Point: 386.478 °C at 760 mmHg
• Flash Point: 187.536 °C
• Appearance: /
• Density: 1.273 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.14±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-4-methylpyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-methylpyrimidine-5-carbonitrile(17321-97-0)
• EPA Substance Registry System: 2-Amino-4-methylpyrimidine-5-carbonitrile(17321-97-0)

Safety Data

• Hazardous Substances Data: 17321-97-0(Hazardous Substances Data)

Usage

General Description

2-Amino-4-methylpyrimidine-5-carbonitrile is a chemical compound with the molecular formula C6H7N5. It is a pyrimidine derivative and has a molecular weight of 141.15 g/mol. 2-Amino-4-methylpyrimidine-5-carbonitrile is commonly used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. It has also been investigated for its potential antitumor and antiviral activities. 2-Amino-4-methylpyrimidine-5-carbonitrile is a versatile building block in organic synthesis and can be used to create a variety of different compounds with diverse applications. Due to its importance in drug development and organic chemistry, research on the properties and potential uses of this compound continues to be of interest in the scientific community.

InChI:InChI=1/C6H6N4/c1-4-5(2-7)3-9-6(8)10-4/h3H,1H3,(H2,8,9,10)

Upstream product

• 17321-93-6 5-bromo-4-methylpyrimidine-2-ylamine 
• 593-85-1 guanidine carbonate 
• 858135-88-3 (E)-2-((dimethylamino)methylene)-3-oxobutanenitrile 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 19594-45-7 5-aminomethyl-4-methyl-pyrimidin-2-ylamine 

Relevant articles and documents

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates

Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.