17324-90-2Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELLULAR PROLIFERATION
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Page/Page column 137, (2019/07/20)
This invention is in the area of heterocyclic-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.
Design and synthesis of certain substituted cycloalkanecarboxamides structurally related to safinamide with anticonvulsant potential
Aboul-Enein, Mohamed N.,El-Azzouny, Aida A.,Maklad, Yousreya A.,Ismail, Mohamed A.,Ismail, Nasser S. M.,Hassan, Rasha M.
, p. 3767 - 3791 (2015/06/08)
A series of novel safinamide derivatives were synthesized and biologically evaluated for their anticonvulsant activity against maximal electroshock seizure assay and subcutaneous pentylenetetrazole (s.c. PTZ) screening test. Compound 13b is the most active derivative in s.c. PTZ screening test with an ED50 value lower than that of safinamide by about tenfold. A molecular modeling study, including fitting to sodium channel blockers 3D-pharmacophore model and docking into a branched-chain aminotransferase enzyme active site were consistent with the in vivo results.
Methods and compositions for treating amyloid-related diseases
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Page/Page column 156, (2010/11/24)
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
Conversion of a ketone to a geminal bisacetamide: Synthesis of 1,1-bisacetamidocyclohexane
Davis, Matthew C.,Stasko, Daniel,Chapman, Robert D.
, p. 2677 - 2684 (2007/10/03)
The synthesis of the title compound (6) is described. A key step in the novel sequence is the Hofmann rearrangement of an α,α-dialkyl-α-aminocarboxamide mediated by hypervalent iodine reagent.
Substituent effect on acidity of substituted 2-(4-nitrobenzoylamino)alkanamidesin methanol-dimethyl sulfoxide mixtures
Mitas, Petr,Sedlak, Milos,Kavalek, Jaromir
, p. 85 - 93 (2007/10/03)
The dissociation constants of substituted 2-(4-nitrobenzoylamino)alkanamides, N-[2-(4-nitrobenzoylamino)aikanoyl]pyrrolidines, and N-alkyl-4-nitrobenzamides have been measured spectrophotometrically in 60 and 80% v/v DMSO. The pKA values of these N-acids are discussed from the point of view of substituents at the acetamide a-carbon atom.
Method for controlling the relative stem growth of plants
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, (2008/06/13)
The invention relates to a method for controlling the relative stem growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of a dihydroimidazoisoindoledione or an optical or stereo isomer thereof.
Method for inhibiting bud growth of plants
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, (2008/06/13)
The invention relates to a method for inhibiting the bud growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of a dihydroimidazoisoindoledione or an optical or stereo isomer thereof.
Method for inhibiting bud growth of plants
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, (2008/06/13)
The invention relates to a method for inhibiting the bud growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of an imidazoisoindoledione or an optical or stereo isomer thereof.
Method for controlling the relative stem growth of plants
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, (2008/06/13)
The invention relates to a method for controlling the relative stem growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of an imidazoisoindoledione or dihydroimidazoisoindoledione or an optical or stereo isomer thereof.
