17326-33-9Relevant academic research and scientific papers
Highly chemoselective multicomponent biginelli-type condensations of cycloalkanones, urea or thiourea and aldehydes
Zhu, Yu-Lin,Huang, Shen-Lin,Pan, Yuan-Jiang
, p. 2354 - 2367 (2005)
The classical Biginelli reaction is considerably extended by use of cycloalkanones instead of 1,3-dicarbonyl compounds. Use of TMSCl as a Lewis acid allowed one-pot chemoselective multicomponent Biginelli reactions between cycloalkanones, urea or thiourea, and aldehydes. Under similar reaction conditions, thiourea exhibited different behavior to urea, and aliphatic aldehydes showed lower reactivity than aromatic aldehydes. A possible mechanism to account for the reaction is proposed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
Aluminium(III) halides mediated synthesis of 5-unsustituted 3,4-dihydropyrimidin-2(1H)-ones via three component Biginelli-like reaction
Saini, Anil,Kumar, Sanjay,Sandhu, Jagir S.
, p. 1690 - 1694 (2008/09/18)
5-Unsubstituted-3,4-dihydropyrimidin-2(1H)-ones have been synthesized in excellent yields in a aluminium(III) halides mediated three component cycloaddition of aldehyde, urea and enolizable ketone.
