Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-γ,γ-difluoromethotrexate

DOI: 10.1021/jm950514m

Source and publish data:

Journal of Medicinal Chemistry p. 66 - 72 (1996)

Update date:2022-08-05

Topics:

Authors:

Tsukamoto, Takashi

Kitazume, Tomoya

McGuire, John J.

Coward, James K.

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Article abstract of DOI:10.1021/jm950514m

DL-4,4-Difluoroglutamic acid (DL-4,4-F₂Glu) and its methotrexate analogue, DL-γ,γ-difluoromethotrexate (DL-γ,γ-F₂MTX), were synthesized and evaluated as alternate substrates or inhibitors of folate-dependent enzymes. Synthesis of DL-

Full text of DOI:10.1021/jm950514m

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