173305-53-8Relevant academic research and scientific papers
Synthesis and structure-activity relationships of novel 3'-Hty- substituted pneumocandins
Black, Regina M.,Balkovec, James M.,Nollstadt, Karl M.,Dreikorn, Sarah,Bartizal, Kenneth F.,Abruzzo, George K.
, p. 2879 - 2884 (1997)
A series of pneumocandin B0 analogs substituted at the 3'-position of the homotyrosine (Hty) residue have been prepared and evaluated for their inhibition of 1,3-β-(D)-glucan synthesis and for their antifungal activity against C. albicans. Cationic analogs displayed enhanced antifungal properties. The phenolic hydroxyl is involved in a critical hydrogen-bond at the binding site of the enzyme.
