Bioorganic and Medicinal Chemistry Letters p. 2879 - 2884 (1997)
Update date:2022-08-04
Topics:
Black, Regina M.
Balkovec, James M.
Nollstadt, Karl M.
Dreikorn, Sarah
Bartizal, Kenneth F.
Abruzzo, George K.
A series of pneumocandin B0 analogs substituted at the 3'-position of the homotyrosine (Hty) residue have been prepared and evaluated for their inhibition of 1,3-β-(D)-glucan synthesis and for their antifungal activity against C. albicans. Cationic analogs displayed enhanced antifungal properties. The phenolic hydroxyl is involved in a critical hydrogen-bond at the binding site of the enzyme.
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