17331-13-4

Usage

Uses

Used in Research Applications:
2'-DEOXY-N2-DIMETHYLAMINOMETHYLENE-GUANOSINE is used as a research tool for studying the structure and function of nucleic acids, providing insights into the fundamental mechanisms of RNA and DNA biology.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2'-DEOXY-N2-DIMETHYLAMINOMETHYLENE-GUANOSINE is utilized as a potential therapeutic agent, targeting nucleic acids for the treatment of various diseases and conditions. Its unique chemical properties allow for the exploration of its interactions with biological systems and its potential to modulate specific cellular processes.

Upstream product

• 1055366-15-8 T₅S₀-O(CO)dGuaAm 

Downstream Products

• 330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 
• 1228304-70-8 C₂₉H₃₀N₆O₆ 
• 1263363-96-7 2'-deoxy-1-{2-[(2,4-dinitrophenyl)amino]ethyl}guanosine 
• 222736-17-6 (5'S)-N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-5',8-cyclo-2'-deoxyguanosine 
• 222736-16-5 (5'S)-N₂-isobutyryl-3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-5',8-cyclo-2'-deoxyguanosine 
• 1350751-83-5 N₂-DMF-5'-phenylthio-2',5'-dideoxyguanosine 
• 1111866-36-4 5'-O-DMT-2'-deoxy-N₂-dimethylaminomethylene-N₁-(6-nitropiperonyloxymethylene)-guanosine 
• 1620233-27-3 5′-O-DMT-N¹-Methyl-N²-DMF-deoxyguanosine 
• 1620233-28-4 5′-O-DMT-N¹-methyl-N²-DMF-deoxyguanosine-3′-cyanoethyl phosphoramidite 
• 1520896-36-9 C₃₄H₃₄N₆O₅ 
• 1111866-37-5 5'-O-DMT-2'-deoxy-N₂-dimethylaminomethylene-N₁-(6-nitropiperonyl-oxymethylene)-guanosine-3'-[(2-cyanoethyl)-N,N-diisopropylaminophosphoramidite] 
• 145432-03-7 C₃₄H₃₇N₆O₈P*C₉H₁₆N₂ 
• 145432-06-0 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxyguanosin-3'-yl phosphonate 
• 40094-22-2 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine 

Relevant academic research and scientific papers

Intramolecular sensitization of photocleavage of the photolabile 2-(2-nitrophenyl)propoxycarbonyl (NPPOC) protecting group: Photoproducts and photokinetics of the release of nucleosides

Novel photolabile protecting groups based on the 2-(2-nitrophenyl)- propoxycarbonyl (NPPOC) group with a covalently linked thioxanthone as an intramolecular triplet sensitizer exhibit significantly enhanced light sensitivity under continuous illumination. Herein we present a detailed study of the photokinetics and photoproducts of nucleosides caged with these new protecting groups. Relative to the parent NPPOC group, the light sensitivity of the new photolabile protecting groups is enhanced by up to a factor of 21 at 366 nm and is still quite high at 405 nm, the wavelength at which the sensitivity of the parent compound is practically zero. A new pathway for de-protection of the NPPOC group pro_ceeding through a nitroso benzylalcohol intermediate has been discovered to complement the main mechanism, which involves β elimination. Under standard conditions of lithographic DNA-chip synthesis, some of the new compounds, while maintaining the same chip quality, react ten times faster than the unmodified NPPOC-protected nucleosides.