40094-22-2

Usage

Uses

Used in Pharmaceutical Industry:
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine is used as a potential therapeutic agent for the treatment of various diseases due to its structural similarities to nucleoside analogs with antiviral and cytotoxic activities.
Used in Antiviral Applications:
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine is used as an antiviral agent, leveraging its structural similarities to nucleoside analogs that have demonstrated antiviral properties.
Used in Cytotoxic Applications:
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine is used as a cytotoxic agent, owing to its potential to exhibit cytotoxic activities similar to other nucleoside analogs.
Used in Medicinal Chemistry Research:
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine is used as a research compound in medicinal chemistry for further investigation of its potential as a pharmaceutical agent and its therapeutic applications in treating various diseases.

Upstream product

• 961-07-9 2'-Deoxyguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 17331-13-4 N²-dimethylaminomethylene-2'-deoxyguanosine 

Downstream Products

• 330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 
• 145432-06-0 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxyguanosin-3'-yl phosphonate 
• 145432-03-7 C₃₄H₃₇N₆O₈P*C₉H₁₆N₂ 

Relevant academic research and scientific papers

ION SENSOR DNA AND RNA SEQUENCING BY SYNTHESIS USING NUCLEOTIDE REVERSIBLE TERMINATORS

This disclosure is related to a method for determining the identity of a nucleotide residue of a single-stranded DNA or RNA, or sequencing DNA or RNA, in a solution using an ion-sensing field effect transistor and reversible nucleotide terminators.

DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS

Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

H-phosphonate DNA synthesis without amino protection

DNA synthesis by the H-phosphonate method does not require the use of amino protecting groups. The cytosine amino group, and the guanine O6/N1 positions, do react with the condensing agent to some extent, but these derivatives are cleaved under the standa

FAST OLIGONUCLEOTIDE DEPROTECTION. PHOSPHORAMIDITE CHEMISTRY FOR DNA SYNTHESIS

A new set of base protecting groups for cyanoethylphosphoramidite nucleosides has been developed which decreases the post-synthesis time requirements.The traditional purine amide protecting groups, which require 8 - 16 hours at 55 deg C for deprotection in ammonia, have been replaced with the dimethylformamidine group.Oligonucleotides made with the new reagents require only 1 hour at 55 deg C or 8 hours at room temperature for complete deprotection.Dialkylformamidine phosphoramidites exhibit enhanced resistance to depurination compared to the traditional, or even the phenoxyacetyl, phosphoramidites.

AUTOMATED CHLORIDITE AND AMIDITE SYNTHESIS OF OLIGODESOXYRIBONUCLEOTIDES ON A LONG CHAIN SUPPORT USING AMIDINE PROTECTED PURINE NUCLEOSIDES

Preparation of solid supports with long aliphatic spacer for the oligonucleotide synthesis is described.Automated synthesis of oligodeoxyribonucleotides using in situ prepared methylchlorophosphite intermediates from amidine protected purine nucleosides i