173326-37-9 Usage
Uses
Used in Pharmaceutical Research:
N-CIS-2,6-DIMETHYLPIPERIDINOCARBONYL-BETA-TBU-ALA-D-TRP(1-METHOXYCARBONYL)-D-NLE-OH is utilized as a research compound for exploring its potential biological activities and pharmacological effects. N-CIS-2,6-DIMETHYLPIPERIDINOCARBONYL-BETA-TBU-ALA-D-TRP(1-METHOXYCARBONYL)-D-NLE-OH's unique structure may offer insights into novel mechanisms of action or therapeutic targets.
Used in Drug Development:
In the pharmaceutical industry, N-CIS-2,6-DIMETHYLPIPERIDINOCARBONYL-BETA-TBU-ALA-D-TRP(1-METHOXYCARBONYL)-D-NLE-OH is employed as a lead compound in the development of new drugs. Its specific structural features could be harnessed to create medications with targeted actions, potentially leading to more effective treatments with fewer side effects.
Used in Peptide Synthesis:
N-CIS-2,6-DIMETHYLPIPERIDINOCARBONYL-BETA-TBU-ALA-D-TRP(1-METHOXYCARBONYL)-D-NLE-OH serves as a building block in the synthesis of larger peptides or protein-based therapeutics. Its incorporation into these molecules may enhance their stability, bioavailability, or therapeutic efficacy.
Used in Chemical Biology:
N-CIS-2,6-DIMETHYLPIPERIDINOCARBONYL-BETA-TBU-ALA-D-TRP(1-METHOXYCARBONYL)-D-NLE-OH is applied in chemical biology as a tool to study the interactions between small molecules and biological targets. Its unique structure may facilitate the discovery of new binding partners or elucidate the mechanisms of biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 173326-37-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,3,2 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 173326-37:
(8*1)+(7*7)+(6*3)+(5*3)+(4*2)+(3*6)+(2*3)+(1*7)=129
129 % 10 = 9
So 173326-37-9 is a valid CAS Registry Number.
173326-37-9Relevant academic research and scientific papers
An efficient preparation of the pseudopeptide endothelin-B receptor selective antagonist BQ-788
He,Cody,Doherty
, p. 8262 - 8266 (2007/10/03)
The endothelins are a family of bicyclic 21 amino acid peptides that are potent and prolonged vasoconstrictors. BQ-788 is a modified tripeptide that is the only known highly potent and selective antagonist for the endothelin-B (ET(B)) receptor subtype discovered to date. Previous preparations of BQ-788 (N-(cis-2,6-dimethylpiperidinocarbonyl)-γ-methylleucyl-D-1-(methoxyca rbonyl)tryptophanyl-D-norleucine sodium salt) have suffered from several synthetic difficulties, including formation of the sterically hindered N-(cis-2,6-dimethylpiperidinocarbonyl)-γ-methylleucine, racemization of tryptophan during carbamination, and the facile reduction of the indole ring of tryptophan during catalytic hydrogenation. In order to prepare sufficient quantities of BQ-788 for in vitro and in vivo evaluations of the physiological significance of the ET(B) receptor, we have developed an efficient solution phase multiple-gram synthetic strategy.
