140897-41-2 Usage
Uses
Used in Pharmaceutical Industry:
L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl-, phenylmethyl ester is used as a protecting group in peptide synthesis for the development of new pharmaceutical drugs. Its ability to prevent unwanted reactions during peptide synthesis allows for the creation of specific peptide sequences, contributing to the advancement of drug discovery and therapeutic applications.
Used in Biochemistry Research:
In the field of biochemistry, L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl-, phenylmethyl ester is utilized as a protecting group in peptide synthesis to facilitate research into various biological processes. Its role in enabling the synthesis of specific peptide sequences with high precision and purity aids scientists in understanding the structure, function, and mechanisms of biological molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 140897-41-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,8,9 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 140897-41:
(8*1)+(7*4)+(6*0)+(5*8)+(4*9)+(3*7)+(2*4)+(1*1)=142
142 % 10 = 2
So 140897-41-2 is a valid CAS Registry Number.
140897-41-2Relevant academic research and scientific papers
He,Cody,Doherty
, p. 8262 - 8266 (1995)
The endothelins are a family of bicyclic 21 amino acid peptides that are potent and prolonged vasoconstrictors. BQ-788 is a modified tripeptide that is the only known highly potent and selective antagonist for the endothelin-B (ET(B)) receptor subtype discovered to date. Previous preparations of BQ-788 (N-(cis-2,6-dimethylpiperidinocarbonyl)-γ-methylleucyl-D-1-(methoxyca rbonyl)tryptophanyl-D-norleucine sodium salt) have suffered from several synthetic difficulties, including formation of the sterically hindered N-(cis-2,6-dimethylpiperidinocarbonyl)-γ-methylleucine, racemization of tryptophan during carbamination, and the facile reduction of the indole ring of tryptophan during catalytic hydrogenation. In order to prepare sufficient quantities of BQ-788 for in vitro and in vivo evaluations of the physiological significance of the ET(B) receptor, we have developed an efficient solution phase multiple-gram synthetic strategy.
