17335-08-9

Basic information

• Product Name: 3(2H)-Pyridazinone, 5-acetyl-4-amino-6-phenyl-
• CAS NO: 17335-08-9
• Molecular Formula: C12H11N3O2
• Molecular Weight: 229.238
• Mol File: 17335-08-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone, 5-acetyl-4-amino-6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 5-acetyl-4-amino-6-phenyl-(17335-08-9)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 5-acetyl-4-amino-6-phenyl-(17335-08-9)

Safety Data

• Hazardous Substances Data: 17335-08-9(Hazardous Substances Data)

Upstream product

• 17335-06-7 ethyl 4-benzoyl-5-methylisoxazole-3-carboxylate 
• 17334-68-8 3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one 

Downstream Products

• 681828-71-7 5-acetyl-4-amino-6-phenyl-2-[(4-phenylpiperazin-1-yl)propyl]-pyridazin-3(2H)-one 
• 681828-94-4 5-acetyl-4-amino-6-phenyl-2-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-2H-pyridazin-3-one 
• 681828-95-5 5-acetyl-4-amino-2-{3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-propyl}-6-phenyl-2H-pyridazin-3-one 
• 136320-11-1 4-amino-5-(1-hydroxyethyl)-6-phenylpyridazin-3(2H)-one 
• 1192490-48-4 4-amino-5-(2-bromoacetyl)-6-phenylpyridazin-3(2H)-one 
• 681829-05-0 4-amino-2-{3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-propyl}-5-(1-hydroxy-ethyl)-6-phenyl-2H-pyridazin-3-one 
• 681829-04-9 4-amino-5-(1-hydroxy-ethyl)-6-phenyl-2-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-2H-pyridazin-3-one 
• 681828-72-8 4-amino-5-hydroxyethyl-6-phenyl-2-[(4-phenylpiperazin-1-yl)propyl]-pyridazin-3(2H)-one 

Relevant articles and documents

4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action

A series of 4-amino-5-vinyl-3(2H)-pyridazinones and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Several of the novel compounds showed ED50 values in the range 6-20 mg/kg/s

4,5-Functionalized 6-phenyl-3(2H)-pyridazinones: synthesis and evaluation of antinociceptive activity

A series of 2-substituted 4,5-functionalized 6-phenyl-3(2H)-pyridazinones were synthesized and their antinociceptive activities were evaluated in the mouse abdominal constriction model.Single dose studies showed that compounds 11, 18a and 23 were more active than the reference drug, Emorfazone, in inhibiting the effects of the noxious chemical stimulus, p-phenylquinone.Subsequent dose-response studies revealed 18a to be almost seven-fold more potent than Emorfazone.Keywords: - Emorfazone; pyridazinone; antinociceptive activity