17335-08-9

Upstream product

• 17335-06-7 ethyl 4-benzoyl-5-methylisoxazole-3-carboxylate 
• 17334-68-8 3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one 

Downstream Products

• 681828-71-7 5-acetyl-4-amino-6-phenyl-2-[(4-phenylpiperazin-1-yl)propyl]-pyridazin-3(2H)-one 
• 681828-94-4 5-acetyl-4-amino-6-phenyl-2-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-2H-pyridazin-3-one 
• 681828-95-5 5-acetyl-4-amino-2-{3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-propyl}-6-phenyl-2H-pyridazin-3-one 
• 136320-11-1 4-amino-5-(1-hydroxyethyl)-6-phenylpyridazin-3(2H)-one 
• 681828-72-8 4-amino-5-hydroxyethyl-6-phenyl-2-[(4-phenylpiperazin-1-yl)propyl]-pyridazin-3(2H)-one 
• 681829-04-9 4-amino-5-(1-hydroxy-ethyl)-6-phenyl-2-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-2H-pyridazin-3-one 
• 681829-05-0 4-amino-2-{3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-propyl}-5-(1-hydroxy-ethyl)-6-phenyl-2H-pyridazin-3-one 

Relevant academic research and scientific papers

4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action

A series of 4-amino-5-vinyl-3(2H)-pyridazinones and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Several of the novel compounds showed ED50 values in the range 6-20 mg/kg/s

Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors

The isoxazolo-[3,4-d]-pyridazin-7-(6H)-one (2) and its corresponding open derivatives 5-acetyl-4-amino-(4-nitro)-6-substituted-3(2H)pyridazinones (3, 4) were used as simplified substrates for the synthesis of new aldose reductase inhibitors with respect t

4,5-Functionalized 6-phenyl-3(2H)-pyridazinones: synthesis and evaluation of antinociceptive activity

A series of 2-substituted 4,5-functionalized 6-phenyl-3(2H)-pyridazinones were synthesized and their antinociceptive activities were evaluated in the mouse abdominal constriction model.Single dose studies showed that compounds 11, 18a and 23 were more active than the reference drug, Emorfazone, in inhibiting the effects of the noxious chemical stimulus, p-phenylquinone.Subsequent dose-response studies revealed 18a to be almost seven-fold more potent than Emorfazone.Keywords: - Emorfazone; pyridazinone; antinociceptive activity

REDUCTIVE CLEAVAGE OF ISOXAZOLOPYRIDAZINONES: A SYNTHETIC APPROACH TO VARIOUS 4,5-FUNCTIONALIZED 3(2H)-PYRIDAZINONES

4-Aminopyridazin-3(2H)-ones substituted at position 5 with a variety of oxygenated carbon chains were obtained in good yields by reductive opening of the pentatomic ring of isoxazolopyridazinones (1).Starting from ethyl 4-acylisoxazole-3-carboxylat