173365-16-7

Upstream product

• 109-70-6 1.3-chlorobromopropane 
• 173365-15-6 ethyl 4-{3-[3-hydroxy-4-(4-methylphenylmethoxy)benzoyl]indol-1-yl}butanoate 
• 152360-09-3 Ethyl 4-[3-(3,4-dihydroxybenzoyl)indol-1-yl]butanoate 
• 104-81-4 4-Methylbenzyl bromide 

Downstream Products

• 173365-14-5 ethyl 4-{3-{4-(4-methylphenylmethoxy)-3-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}benzoyl}-indol-1-yl}butanoate 

Relevant academic research and scientific papers

Dual-acting agents with α1-adrenoceptor antagonistic and steroid 5α- reductase inhibitory activities. Synthesis and evaluation of arylpiperazine derivatives

A series of arylpiperazine derivatives were prepared and evaluated for their α1-adrenoceptor antagonistic activities and 5α-reductase inhibitory activities. SAR study led to the identification of the potent dual-acting compound 2f, which had a pA2 value of 7.5 for α1-adrenoceptor antagonism and an IC50 value of 1.5 nM for 5α-reductase inhibition.

Indole derivative for treating overproduction of dihydrotestosterone

The present invention relates to an indole derivative represented by formula (1) or a salt thereof, and a pharmaceutical containing the derivative or the salt: STR1 wherein R 1 represents lower alkyl; R 2 represents hydrogen or phenyl which may be substit