173411-50-2Relevant academic research and scientific papers
BICYCLIC FUSED PYRIMIDINE COMPOUNDS AS TAM INHIBITORS
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Page/Page column 80-81, (2017/03/14)
This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
The chemistry of pseudomonic acid. 15. Synthesis and antibacterial activity of a series of 5-alkyl, 5-alkenyl, and 5-heterosubstituted oxazoles
Brown, Pamela,Davies, David T.,O'Hanlon, Peter J.,Wilson, Jennifer M.
, p. 446 - 457 (2007/10/03)
The synthesis of a range of 5-alkyl, 5-alkenyl, and 5-heterosubstituted 2- (1-normon-2-yl) oxazoles is described. The antibacterial activity was determined as the minimum inhibitory concentration against a range of Gram- positive and Gram-negative organisms using a standard Agar dilution procedure. Compounds possessing an acid functionality directly on, or close to, the ring were found to be of greatly decreased potency, while increasing lipophilicity with greater chain length led to increased potency of these derivatives.
