17343-99-6

Basic information

• Product Name: 2-acetylcyclooctanone
• Synonyms: 2-Acetyl-cyclooctanone
• CAS NO: 17343-99-6
• Molecular Formula: C₁₀H₁₆O₂
• Molecular Weight: 168.2328
• Mol File: 17343-99-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 277.6°C at 760 mmHg
• Flash Point: 103.1°C
• Density: 0.991g/cm³
• Vapor Pressure: 0.00449mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: 2-acetylcyclooctanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetylcyclooctanone(17343-99-6)
• EPA Substance Registry System: 2-acetylcyclooctanone(17343-99-6)

Safety Data

• Hazardous Substances Data: 17343-99-6(Hazardous Substances Data)

Usage

General Description

2-acetylcyclooctanone is a chemical compound with the molecular formula C10H16O2. It is a cyclic ketone that contains a cyclooctane ring with an acetyl functional group attached at the second carbon position. 2-acetylcyclooctanone is used in organic synthesis and pharmaceutical research, and it has been studied for its potential pharmacological properties. 2-acetylcyclooctanone exhibits moderate solubility in water and is typically handled and stored under inert gas to prevent oxidation. Its unique structure and properties make it a valuable building block for the production of various organic compounds and potential drug candidates.

Upstream product

• 502-49-8 cycloactanone 
• 75-36-5 acetyl chloride 
• 101471-72-1 1-(morpholin-4-yl)cyclooctene 
• 101471-72-1 1-morpholinocyclooctene 
• 108-24-7 acetic anhydride 

Downstream Products

• 1204395-53-8 4-acetyl-3-phenyl-3-cyclodecenone 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolins as potential EZH2 inhibitors

The histone lysine methyltransferase EZH2 has been implicated as a key component in cancer aggressiveness, metastasis and poor prognosis. This study discovered a new class of hexahydroisoquinolin derivatives as EZH2 inhibitors. A structure-activity relationship study showed that the steric hindrance was important to the activity for EZH2. A preliminary optimization study led to the discovery of several potent compounds with low nanomolar to sub-nanomolar potency for EZH2. Biological evaluation indicated that SKLB1049 was a highly potent with improved solubility compared to EPZ6438, SAM-competitive, and cell-active EZH2 inhibitor that decreased global H3K27me3 in SU-DHL-6 and Pfeiffer lymphoma cells in a concentration- and time-dependent manner. Further study indicated that SKLB1049 caused cell arrest in G0/G1 phase. These compounds would be useful as chemical tools to further explore the biology of EZH2 and provided us with a start point to develop new EZH2 inhibitors.