173436-66-3

Usage

Uses

Used in Pharmaceutical Industry:
Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester is used as an active pharmaceutical ingredient for its anti-inflammatory and antibacterial properties. It is employed in the development of new drugs to treat various inflammatory and bacterial infections.
Used in Chemical Industry:
In the chemical industry, benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester is used as an intermediate in the synthesis of other chemical compounds. Its unique structure and functional groups make it a valuable building block for the creation of novel molecules with potential applications in various fields.
Used in Drug Synthesis:
Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester is used as a key component in the synthesis of novel drug molecules. Its versatile structure allows for the development of new compounds with improved therapeutic properties and targeted effects on specific biological pathways.
Overall, benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester is a promising compound with a wide range of applications in the pharmaceutical and chemical industries. Its potential biological activities and versatility in synthesis make it an important candidate for further research and development.

Upstream product

• 4518-10-9 Methyl 3-aminobenzoate 
• 98-59-9 p-toluenesulfonyl chloride 
• 618-91-7 methyl 3-iodo-benzoate 
• 70-55-3 toluene-4-sulfonamide 
• 4124-41-8 p-toluenesulfonylanhydride 
• 618-95-1 methyl 3-nitrobenzoate 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Relevant academic research and scientific papers

Metal-Free Catalyzed Cyclization of N-Methoxybenzamides to Construct Quaternary Carbon-Containing Isoindolinones

Through the intramolecular cyclization of N-methoxybenzamides, a simple and efficient method for constructing valuable isoindolinones under metal-free conditions was developed. The reaction was featured by employing low-cost catalyst, simple operation, 100% atomic economy and excellent regioselectivity. Moreover, a detailed computational study on the reaction system has been performed to clarify the mechanism. This protocol tolerated a variety of functional groups and provided a metal-free protocol for the synthesis of chromane- or tetrahydroquinoline-fused isoindolinones in good yields.

Pyrazole compound, preparation method and application thereof, and pharmaceutical composition

The invention relates to a substituted pyrazole compound, a preparation method and application thereof, and a pharmaceutical composition, wherein the pyrazole compound is represented by a formula (I),is an STAT3 signal channel inhibitor, and can be used for preventing and/or treating diseases related to STAT3 activity, such as tumors, autoimmune diseases, kidney diseases, cardiovascular diseases,inflammatory diseases, metabolic/endocrine dysfunction or neurological diseases.

Fe-based metal-organic frameworks for the synthesis of N-arylsulfonamides via the reactions of sodium arylsulfinates or arylsulfonyl chlorides with nitroarenes in water

A newly developed chemoselective reaction of sodium arylsulfinates or arylsulfonyl chlorides with nitroarenes has been disclosed. The chemistry, in which non-toxic water and recyclable iron-based metal-organic frameworks are employed as the solvent and catalyst, respectively, provides an efficient approach for the generation of N-arylsulfonamides, which are widely present in biologically active compounds and drugs, rendering this methodology attractive to both synthetic and medicinal chemistry.

Iron-catalyzed N -arylsulfonamide formation through directly using nitroarenes as nitrogen sources

One-step, catalytic synthesis of N-arylsulfonamides via the construction of N-S bonds from the direct coupling of sodium arylsulfinates with nitroarenes was realized in the presence of FeCl2 and NaHSO3 under mild conditions. In this process, stable and readily available nitroarenes were used as nitrogen sources, and NaHSO3 acted as a reductant to provide N-arylsulfonamides in good to excellent yields. A broad range of functional groups were very well-tolerated in this reaction system. In addition, mechanistic studies indicated that the N-S bond might be generated through direct coupling of nitroarene with sodium arylsulfinate prior to the reduction of nitroarenes by NaHSO3. Accordingly, a reaction mechanism involving N-aryl-N-arenesulfonylhydroxylamine as an intermediate was proposed.

Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and carbamates

A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines. These reactions tend to be quick (30 min), high-yielding, and tolerate a range of other functional groups. Replacement of PMHS/KF with triethylsilane allows for the reduction of aliphatic nitro compounds to their corresponding hydroxylamines. Depending on the substrate, both conditions can allow for the in situ conversion of the product amines into amides, sulfonamides, and carbamates. Georg Thieme Verlag Stuttgart.

Copper-catalyzed cross-coupling of sulfonamides with aryl iodides and bromides facilitated by amino acid ligands

A highly general, convenient, and inexpensive catalyst system was developed for the N-arylation of sulfonamides with aryl iodides or bromides by using 5-20 mol % of CuI as catalyst, 20 mol % of N-methylglycine (for aryl iodides) or N,N-dimethylglycine (for aryl bromides) as ligand, and K3PO 4 as base.

Solid phase synthesis of sulfonamides using a carbamate linker

A method for the synthesis of sulfonamides on a solid support by immobilizing amines through the nitrogen atom using a carbamate linkage is described.