173469-03-9

Basic information

• Product Name: Pyridine, 4-(2-phenyl-1H-pyrrol-3-yl)-
• CAS NO: 173469-03-9
• Molecular Formula: C15H12N2
• Molecular Weight: 220.274
• Mol File: 173469-03-9.mol

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(2-phenyl-1H-pyrrol-3-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(2-phenyl-1H-pyrrol-3-yl)-(173469-03-9)
• EPA Substance Registry System: Pyridine, 4-(2-phenyl-1H-pyrrol-3-yl)-(173469-03-9)

Safety Data

• Hazardous Substances Data: 173469-03-9(Hazardous Substances Data)

Upstream product

• 100-43-6 4-vinylpyridine 
• 202286-41-7 N-(benzotriazol-1-ylmethyl)-α-(methylthio)phenylimine 
• 117067-55-7 N-(benzotriazol-1-ylmethyl)thiobenzoamide 

Relevant articles and documents

Heteroaryl-substituted pyrrole derivates, their preparation and their therapeutic uses

Compounds of formula (I): [wherein: A is a pyrrole ring; R1 is an optionally substituted phenyl or naphthyl group; R2 is an optionally substituted pyridyl or pyrimidinyl group; R3 represents a group of the formula -X-R4, wherein X is a single bond or an alkenylene group, and R4 is an optionally substituted nitrogen-containing heterocyclyl group; selected from the group consisting of 8-azabicyclo[3.2.1]octenyl, 9-azabicyclo[3.3.1]nonenyl and quinuclidinenyl groups, PROVIDED THAT said substituents R1 and R3 are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2 is bonded] have excellent inhibitory activity against the production of inflammatory cytokines.

Novel and convenient routes to substituted pyrroles and imidazoles

S-Methyl N-(benzotriazol-1-ylmethyl)thioimidate 6 is obtained by lithiation of the corresponding N-(benzotriazol-1-ylmethyl)thioamide 5 and subsequent reaction with methyl iodide. Derivative 6 undergoes [2+3] cycloaddition reactions with α,β-unsaturated -esters, -ketones and -nitriles, and vinylpyridines which are followed by elimination of benzotriazole and the thioalkoxy group, to give 2,3,4-trisubstituted pyrroles. Lithiation of 6 followed by reactions with imines gives cyclized 4,5-dihydroimidazoles 14 which upon further treatment with ZnBr2 or direct refluxing in toluene yield the 1,2,5-trisubstituted imidazoles 15 in good yields.