1735-87-1

Usage

Uses

Used in Organic Synthesis:
2,2-Bis(trifluoromethyl)propionyl fluoride is used as a reagent for the formation of trifluoromethyl ketones, which are valuable intermediates in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its ability to introduce trifluoromethyl groups into organic molecules enhances their properties, such as lipophilicity and metabolic stability.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2-Bis(trifluoromethyl)propionyl fluoride is employed as a fluorinating agent to incorporate fluorine atoms into drug molecules. The introduction of fluorine can improve the pharmacokinetic and pharmacodynamic properties of drugs, such as their solubility, bioavailability, and receptor binding affinity.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 2,2-Bis(trifluoromethyl)propionyl fluoride is used as a fluorinating agent to enhance the performance of agrochemicals. The incorporation of fluorine atoms can improve the effectiveness, selectivity, and environmental persistence of these compounds.
Safety Precautions:
Due to its highly reactive nature and potential for hazardous reactions, 2,2-Bis(trifluoromethyl)propionyl fluoride should be handled and stored with extreme caution in a controlled laboratory environment. Proper safety measures, such as wearing protective clothing, using fume hoods, and following established protocols, are essential to minimize risks associated with its use.

Upstream product

• 360-53-2 1,3,3,3-tetrafluoro-1-methoxy-2-trifluoromethyl-propene 
• 382-22-9 3,3,3-trifluoro-2-trifluoromethyl-propionyl fluoride 
• 74-88-4 methyl iodide 

Downstream Products

• 1736-33-0 α-Methyl-hexafluoroisobuttersaeure-anilid 
• 382-09-2 1,1,1,3,3,3-hexafluoro-2-methyl-propane 
• 2253-00-1 1,1,3,3,3-pentafluoro-2-methyl-1-propene 

Relevant academic research and scientific papers

Exchange reactions of organotin and organosilicon compounds with vinylic fluorine

Compounds carrying reactive fluorine atoms, such as methylphosphonis difluoride and perfluoroisobutene, undergo facile exchange with organosilanes and stannanes.Reactions with protic nucleophiles also yield similar products.To account for the products formed and observed reactivity differences, appropriate mechanisms are proposed.The reactions described herein have considerable synthetic utility.

Synthesis of 1-aroyl(1-arylsulfonyl)-4-bis(trifluoromethyl)alkyl semicarbazides as potential physiologically active compounds

1,1-Bis(trifluoromethyl)alkyl isocyanates obtained from perfluoroisobutene (PFIB) react with aroyl(arylsulfonyl)hydrazines. Twenty eight prospective biologically active polyfluorinated 1,4-substituted semicarbazides were synthesized. The structure of each

Synthesis and anticancer activity of N-bis(trifluoromethyl)alkyl-N′-thiazolyl and N-bis(trifluoromethyl)alkyl-N′-benzothiazolyl ureas

A number of N-bis(trifluoromethyl)alkyl-N′-thiazolyl and -benzothiazolyl ureas have been synthesized and evaluated for their in vitro antiproliferative activities against the human cancer cell lines at the National Cancer Institute (NCI, USA). The activity was shown for compounds 8a,c and 9a-c. The most sensitive cell lines relative to the tested compounds are: 8c PC-3 (prostate cancer, log GI50 -7.10), 9c SNB-75 (CNS cancer, log GI50 -5.84), 9b UO-31 (renal cancer, log GI50 -5.66), and SR (leukemia, log GI50 -5.44) human cancer cells.

CONVERSION OF METHOXYPERFLUOROISOBUTENE TO α-METHYLHEXAFLUOROISOBUTYRIC ACID FLUORIDE BY A PHASE TRANSFER CATALYST

Methoxyperfluoroisobutene was converted to α-methylhexafluoroisobutyric acid fluoride by a catalytic amount of phase transfer catalyst in quantitative yield.