173558-63-9

Upstream product

• 1088-80-8 L-m-sarcolysin 
• 36724-68-2 (S)-N-trifluoroacetylproline acid chloride 
• 174019-19-3 L-N-acetyl-(m-bis-hydroxyethylamino)-phenylalanine methyl ester 
• 173558-69-5 (S)-2-Acetylamino-3-{3-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid methyl ester 
• 621-44-3 3-nitro-L-tyrosine 
• 173558-68-4 L-N-acetyl-3-aminophenyl-alanine methyl ester 

Downstream Products

• 173558-64-0 N-trifluoroacetyl-L-propyl-L-m-sarcolysil-L-norvaline ethyl ester 
• 38232-20-1 (S)-2-{(S)-3-{3-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-pentanoic acid 

Relevant academic research and scientific papers

Acidic coupling and aminolytic TFA cleavage approaches in a new synthesis of an L-m-sarcolysin containing antitumor tripeptide ester

L-propyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester hydrochloride, 4 (and its 3H and 14C doubly-labeled version) was synthesized starting with reacting unprotected L-m-sarcolysin, 1, with TFA-Pro-Cl in an acidic system to yield TFA-Pro-L-m-sarcolysin, 2, which was transformed to the TFA-tripeptide ethyl ester, 3. Selective aminolytic cleavage of the TFA group with butylamine in abs. ethanol, followed by neutralization with HCl gave 4.