38232-20-1

Basic information

• Product Name: Prolyl-m-(bis(chloroethyl)amino)phenylalanyl-norvaline ethyle ester hydrochloride
• Synonyms: Prolyl-m-(bis(chloroethyl)amino)phenylalanyl-norvaline ethyle ester hydrochloride;MF 13
• CAS NO: 38232-20-1
• Molecular Formula: C₂₃H₃₄Cl₂N₄O₄
• Molecular Weight: 501.44646
• Mol File: 38232-20-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 800.6°Cat760mmHg
• Flash Point: 438°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 4.75E-27mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: Prolyl-m-(bis(chloroethyl)amino)phenylalanyl-norvaline ethyle ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Prolyl-m-(bis(chloroethyl)amino)phenylalanyl-norvaline ethyle ester hydrochloride(38232-20-1)
• EPA Substance Registry System: Prolyl-m-(bis(chloroethyl)amino)phenylalanyl-norvaline ethyle ester hydrochloride(38232-20-1)

Safety Data

• Hazardous Substances Data: 38232-20-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C23H34Cl2N4O4/c1-2-5-19(23(32)33)27-22(31)20(28-21(30)18-8-4-11-26-18)15-16-6-3-7-17(14-16)29(12-9-24)13-10-25/h3,6-7,14,18-20,26H,2,4-5,8-13,15H2,1H3,(H,27,31)(H,28,30)(H,32,33)/t18-,19-,20-/m0/s1

Upstream product

• 173558-63-9 trifluoroacetyl-L-propyl-m--L-phenylalanine 
• 174019-19-3 L-N-acetyl-(m-bis-hydroxyethylamino)-phenylalanine methyl ester 
• 173558-69-5 (S)-2-Acetylamino-3-{3-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid methyl ester 
• 173558-68-4 L-N-acetyl-3-aminophenyl-alanine methyl ester 
• 621-44-3 3-nitro-L-tyrosine 
• 1088-80-8 L-m-sarcolysin 
• 39256-85-4 ethyl 2-amino-L-butyrate 
• 173558-64-0 N-trifluoroacetyl-L-propyl-L-m-sarcolysil-L-norvaline ethyl ester 

Relevant articles and documents

Acidic coupling and aminolytic TFA cleavage approaches in a new synthesis of an L-m-sarcolysin containing antitumor tripeptide ester

L-propyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester hydrochloride, 4 (and its 3H and 14C doubly-labeled version) was synthesized starting with reacting unprotected L-m-sarcolysin, 1, with TFA-Pro-Cl in an acidic system to yield TFA-Pro-L-m-sarcolysin, 2, which was transformed to the TFA-tripeptide ethyl ester, 3. Selective aminolytic cleavage of the TFA group with butylamine in abs. ethanol, followed by neutralization with HCl gave 4.