173593-25-4 Usage
Description
Dicyclohexyl(2-methylphenyl)phosphine, also known as PCy2(o-Tol), is a phosphorus ligand characterized by its high melting point, ease of handling, and low susceptibility to oxidation. These unique features make it an ideal catalyst for various coupling reactions in the field of organic chemistry.
Uses
Used in Chemical Synthesis:
Dicyclohexyl(2-methylphenyl)phosphine is used as a catalyst in chemical synthesis for the formation of (Z)-β-chloro-α,β-unsaturated ketones. It is often combined with [IrCl(cod)]2 to form a complex that catalyzes the addition of aliphatic acid chlorides to terminal alkynes, resulting in the desired product with high selectivity and efficiency.
Used in Catalyst Development:
Due to its stability and reactivity, dicyclohexyl(2-methylphenyl)phosphine is used in the development of new catalysts for various organic reactions. Its unique properties allow it to be a promising candidate for improving the efficiency and selectivity of catalytic processes in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, dicyclohexyl(2-methylphenyl)phosphine can be used as a catalyst in the synthesis of complex organic molecules, including potential drug candidates. Its ability to facilitate selective coupling reactions can contribute to the development of novel and effective therapeutic agents.
Used in Material Science:
Dicyclohexyl(2-methylphenyl)phosphine can also be employed in material science for the synthesis of advanced materials with specific properties. Its catalytic activity can be utilized to create new polymers, composites, or other materials with applications in various fields, such as electronics, energy, or environmental protection.
Check Digit Verification of cas no
The CAS Registry Mumber 173593-25-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,5,9 and 3 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 173593-25:
(8*1)+(7*7)+(6*3)+(5*5)+(4*9)+(3*3)+(2*2)+(1*5)=154
154 % 10 = 4
So 173593-25-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H29P/c1-16-10-8-9-15-19(16)20(17-11-4-2-5-12-17)18-13-6-3-7-14-18/h8-10,15,17-18H,2-7,11-14H2,1H3
173593-25-4Relevant articles and documents
A Lewis Base Nucleofugality Parameter, NFB, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics
Taylor, Nicholas P.,Gonzalez, Jorge A.,Nichol, Gary S.,García-Domínguez, Andrés,Leach, Andrew G.,Lloyd-Jones, Guy C.
supporting information, p. 721 - 729 (2022/01/04)
The kinetics of quinuclidine displacement of BH3 from a wide range of Lewis base borane adducts have been measured. Parameterization of these rates has enabled the development of a nucleofugality scale (NFB), shown to quantify and predict the leaving group ability of a range of other Lewis bases. Additivity observed across a number of series R′3-nRnX (X = P, N; R′ = aryl, alkyl) has allowed the formulation of related substituent parameters (nfPB, nfAB), providing a means of calculating NFB values for a range of Lewis bases that extends far beyond those experimentally derived. The utility of the nucleofugality parameter is explored by the correlation of the substituent parameter nfPB with the hydrolyses rates of a series of alkyl and aryl MIDA boronates under neutral conditions. This has allowed the identification of MIDA boronates with heteroatoms proximal to the reacting center, showing unusual kinetic lability or stability to hydrolysis.
