1736-74-9

Basic information

• Product Name: 4-(Trifluoromethoxy)benzyl alcohol
• Synonyms: 4-Trifluoromethoxybenzylalchol;P-TRIFLUOROMETHOXYBENZYLALCHOL ;4-(Trifluoromethoxy)benzyl alcohol 97%;4-(Trifluoromethoxy)benzylalcohol97%;trifluoroMethoxy-p-hydroxyMethylbenzene;RARECHEM AL BD 0284;P-(TRIFLUOROMETHOXY)BENZYL ALCOHOL;[4-(TRIFLUOROMETHOXY)PHENYL]METHANOL
• CAS NO: 1736-74-9
• Molecular Formula: C₈H₇F₃O₂
• Molecular Weight: 192.14
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohol;Alcohols;C7 to C8;Oxygen Compounds;Building Blocks;C7 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 1736-74-9.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 108 °C25 mm Hg(lit.)
• Flash Point: 209 °F
• Appearance: clear light pink liquid
• Density: 1.326 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.169mmHg at 25°C
• Refractive Index: n20/D 1.449(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol
• PKA: 14.03±0.10(Predicted)
• BRN: 1950379
• CAS DataBase Reference: 4-(Trifluoromethoxy)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trifluoromethoxy)benzyl alcohol(1736-74-9)
• EPA Substance Registry System: 4-(Trifluoromethoxy)benzyl alcohol(1736-74-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1736-74-9(Hazardous Substances Data)

Usage

Chemical Properties

clear light pink liquid

Uses

Different sources of media describe the Uses of 1736-74-9 differently. You can refer to the following data:
1. 4-(Trifluoromethoxy)benzyl alcohol is used in biological processes as substrate specificity of inducible O-demethylase of Sporomusa ovata for methoxynaphthols, methoxyfuran and fluoroanisols under anaerobic conditions.
2. 4-(Trifluoromethoxy)benzyl alcohol may be used in chemical synthesis.

General Description

4-(Trifluoromethoxy)benzyl alcohol is an organic building block.

InChI:InChI=1/C8H7F3O2/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-4,12H,5H2

Upstream product

• 587-18-8 4-trifluoromethoxy-benzoic acid ethyl ester 
• 330-12-1 4-trifluoromethoxybenzoic acid 
• 706-27-4 p-methyl-α,α,α-trifluoromethoxybenzene 
• 175277-18-6 4-trifluoromethoxybenzoyl hydrazine 
• 780-31-4 methyl 4-(trifluoromethoxy)benzoate 
• 332-25-2 4-(trifluoromethoxy)benzonitrile 
• 659-28-9 p-trifluoromethoxybenzaldehyde 

Downstream Products

• 659-28-9 p-trifluoromethoxybenzaldehyde 
• 50824-05-0 4-trifluoromethoxybenzyl bromide 
• 438049-40-2 piperazine-1,4-dicarboxylic acid tert-butyl ester 4-trifluoromethoxy-benzyl ester 
• 65796-00-1 1-(chloromethyl)-4-(trifluoromethoxy)benzene 
• 1253202-37-7 4-(trifluoromethoxy)benzyl trichloroacetimidate 
• 1381785-82-5 N-(4-Trifluoromethoxybenzyl)-N-(7-trifluoromethyl-3-methylimidazo[1,2-a]pyridin-2-yl)-2-hydroxyethylsulfonamide 
• 1381785-83-6 N-(4-Trifluoromethoxybenzyl)-N-(7-trifluoromethyl-3-methylimidazo[1,2-a]pyridin-2-yl)-2-bromoethylsulfonamide 
• 1381785-17-6 N-(4-Trifluoromethoxybenzyl)-N-(7-trifluoromethyl-3-methylimidazo[1,2-a]pyridin-2-yl)-2-(N,N-diisobutylamino)ethylsulfonamide 
• 1093980-84-7 1-(azidomethyl)-4-(trifluoromethoxy)benzene 

Relevant articles and documents

ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND

The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBN E3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBN E3 ubiquitin ligase.

Mild oxidation of benzyl alcohols to benzyl aldehydes or ketones catalyzed by visible light

Induced by visible light, mild oxidation condition to prepare benzyl aldehydes or ketones have been developed by using bromotrichloromethane as photochemical oxidant. This method avoids high temperature, pressure and peroxidation with only visible light as the green driving force.

A method of synthesis of primary alcohol (by machine translation)

The invention discloses a method for synthesizing a primary alcohol, using transition metal catalysis, the use of isopropanol as a hydrogen source to synthesize primary alcohol, the reaction not only using a cheap, environmental protection of isopropanol as a hydrogen source and solvent, and has high yield, environmental protection and the like, so that the reaction has broad prospects for development. (by machine translation)