17364-26-0Relevant academic research and scientific papers
Synthesis and biological activity of some lysing and fusogenically active phosphocholine derivatives
Nuhn,Kertscher,Dobner,Braune,Kluge
, p. 706 - 708 (2007/10/02)
2-Hexadecylglycerophosphocholine (1) and its 1-O-methyl, 1-O-ethyl and 1-O-benzyl (4) derivatives as well as some n-alkanol phosphocholines were synthetized and tested for haemolytic activity. Most potent (LD50 approximately equal to 5.10(-6) mol/l) were 1 and the hexadecanol and octadecanol phosphocholines (7 and 8). 1, 4 and 7 were tested for fusogenic activity against vegetable protoplasts. When used at sublytic concentrations (0.01 - 0.05 mmol), these compounds were as efficient as polyethylene glycol.
