173653-35-5Relevant academic research and scientific papers
Fluoride-labile protecting groups for the synthesis of base-sensitive methyl-SATE oligonucleotide prodrugs
Guerlavais-Dagland, Typhaine,Meyer, Albert,Imbach, Jean-Louis,Morvan, Francois
, p. 2327 - 2335 (2003)
Base-sensitive methyl-SATE oligonucleotide prodrugs (prooligos) were synthesized using fluoride-labile protection groups on the nucleobases and on certain internucleosidic phosphate linkages. The combination of [(tert-butyl)(diphenyl)silyloxymethyl]benzoy
Silyl protecting groups for oligonucleotide synthesis removed by a ZnBr2 treatment
Ferreira, Fernando,Morvan, Francois
, p. 1009 - 1013 (2007/10/03)
An oligonucleotide protected with N-(trimethylsilyloxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups was synthesized and deprotected by a single ZnBr2 treatment. Finally it was released from the solid support by cleavage of a disul
Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogues
Ferreira, Fernando,Vasseur, Jean-Jacques,Morvan, Fran?ois
, p. 6287 - 6290 (2007/10/03)
a- a- a- Oligonucleotides protected with N-(trimethylsilylethoxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups were synthesized and deprotected by a single ZnBr2 treatment. Teoc group stabilized dA against depurination. This strategy was applied to the synthesis of base-sensitive oligonucleotide prodrugs bearing S-acetyl-2-thioethyl (Sate) phosphotriesters.
Phosphorothioate: β-Fragmentierung gegen β-Silicium-Effekt
Krotz, Achim H.,Wheeler, Patrick,Ravikumar, Vasulinga T.
, p. 2584 - 2587 (2007/10/03)
Keywords: Antisense-Oligonucleotide, Nachbargruppeneffekte, Nucleotide, Phosphorverbindungen, Umlagerungen
2-(Trimethylsilyl)ethyl as a Phosphate Protecting Group in Oligonucleotide Synthesis
Wada, Takeshi,Sekine, Mitsuo
, p. 757 - 760 (2007/10/02)
The 2-(trimethylsilyl)ethyl (TSE) group was found to be effective as a protecting group for the internucleotidic phosphate in oligonucleotide synthesis.Phosphoramidite building blocks having the TSE group were prepared in good yields.In the case of deoxyg
