173676-52-3

Upstream product

• 17878-42-1 4-((trimethylsilyl)oxy)phenyl magnesium bromide 
• 173676-53-4 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-phenoxy-2H-chromene 
• 173676-31-8 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2H-chromen-2-ol 
• 173676-30-7 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-chromen-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 3173-00-0 7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one 

Downstream Products

• 130064-36-7 2-[4-[2-(1-piperidino)-ethoxy]phenyl]-3-[4-hydroxyphenyl]-7-hydroxy-2H-1-benzopyran 

Relevant academic research and scientific papers

Novel methodology for the synthesis of estrogenic and antiestrogenic isoflav-3-enes

A novel and selective method for the introduction of substituents at the 2-position of the isoflav-3-ene nucleus, utilizing readily available 3-arylcoumarins as starting materials, is described. Thus, addition of a Grignard reagent to the corresponding phenyl acetal provided the desired 2-alkyl-, alkenyl-, or arylisoflav-3-enes. These compounds interact strongly with the estrogen receptor and show estrogenic or antiestrogenic effects depending upon the nature of the 2-substituent.