173677-08-2Relevant academic research and scientific papers
Approaches to short-acting neuromuscular blocking agents: Nonsymmetrical bis-tetrahydroisoquinolinium mono- and diesters
Dhar, Nirmal C.,Maehr, Robert B.,Masterson, Luke A.,Midgley, John M.,Stenlake, John B.,Wastila, William B.
, p. 556 - 561 (2007/10/03)
Nonsymmetrical bisquaternary mono- and diesters combining the potency- enhancing properties of the (1R)-laudanosinium group with a second unhindered quaternary ammonium moiety have been studied as a means of promoting short action with high-potency neuromuscular block. Atracurium-related nonsymmetrical diesters showed high potency, freedom from vagal blockade at neuromuscular blocking doses, and short action. Nonsymmetrical monoesters were short acting but showed varying degrees of vagal block.
