173690-53-4

Usage

Uses

Used in Peptide Synthesis:
FMOC-(4-aminophenyl)acetic acid is used as a protecting group for amines in peptide synthesis. Its application is crucial for preventing unwanted side reactions during the synthesis process, ensuring the correct formation of peptide bonds and facilitating the production of the desired peptide sequence.
Used in Organic Chemistry:
In the realm of organic chemistry, FMOC-(4-aminophenyl)acetic acid serves as a valuable intermediate. Its 4-aminophenylacetic acid component is a key building block for synthesizing a variety of organic molecules, contributing to the development of new compounds with potential applications in various fields.
Used in Pharmaceutical Compounds Synthesis:
FMOC-(4-AMINOPHENYL)ACETIC ACID is also utilized in the synthesis of pharmaceutical compounds, where its structural elements can be incorporated into drug molecules to enhance their therapeutic properties or improve their pharmacokinetic profiles.
Used in Research and Development:
FMOC-(4-aminophenyl)acetic acid is employed in research and development settings to explore new methods of peptide synthesis and to study the properties of the FMOC protecting group and its impact on the synthesis process.

Upstream product

• 1197-55-3 4-aminophenylacetic acid 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 894787-30-5 ST2825 
• 1252806-73-7 5-isoxazoyl-Cha-Ile-4-aminophenyl-(4-[aminomethyl]piperidin-1-yl)ethan-2-one 

Relevant academic research and scientific papers

Solid-phase synthesis of disubstituted guanidines

A method for the solid-phase synthesis of disubstituted guanidines is reported. In this procedure, polymer-bound aryl or alkyl amines are converted to methyl isothioureas in three steps and treated with primary and secondary amines to form the disubstitut

Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture

The viral serine protease NS2B-NS3 is one of the promising targets for drug discovery against dengue virus and other flaviviruses. The molecular recognition preferences of the protease favor basic, positively charged moieties as substrates and inhibitors, which leads to pharmacokinetic liabilities and off-target interactions with host proteases such as thrombin. We here present the results of efforts that were aimed specifically at the discovery and development of noncharged, small-molecular inhibitors of the flaviviral proteases. A key factor in the discovery of these compounds was a cellular reporter gene assay for the dengue protease, the DENV2proHeLa system. Extensive structure-activity relationship explorations resulted in novel benzamide derivatives with submicromolar activities in viral replication assays (EC50 0.24 μM), selectivity against off-target proteases, and negligible cytotoxicity. This structural class has increased drug-likeness compared to most of the previously published active-site-directed flaviviral protease inhibitors and includes promising candidates for further preclinical development.

Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids

Boronic acids are an increasingly important compound class for many applications, including C-C bond formation reactions, medicinal chemistry, and diagnostics. The deprotection of boronic ester intermediates is frequently a problematic and inefficient step in boronic acid syntheses. We describe an approach that highly facilitates this transformation by leveraging the volatility of methylboronic acid and its diol esters. The method is performed under mild conditions, provides high yields, and eliminates cumbersome and problematic purification steps.

Maytansinoid derivatives with peptide linker and conjugates thereof

The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (I). The invention also provides novel cytotoxic agents of formula (II), linker compounds represented by fo

Preparation of 16β-estradiol derivative libraries as bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 using the multidetachable sulfamate linker

Combinatorial chemistry is a powerful tool used to rapidly generate a large number of potentially biologically active compounds. In our goal to develop bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that interact with both th

AMINO ACID ANALOGUES

In particular we have identified novel compounds which enhance the entry of L-arginine into cells. These compounds improve endothelial function, and thereby have the potential to retard the progression of vascular disease in conditions such as hypertension, heart failure and diabetes. This new class of drugs may also have other potentially, relevant pharmacological actions, including anti-hypertensive and anti-anginal actions.