173724-95-3Relevant articles and documents
Preparation method of chiral 3-substituted pyrrolidine derivative
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Paragraph 0064-0067, (2020/11/01)
The invention provides a preparation method of a chiral 3-substituted pyrrolidine derivative. The preparation method comprises an intermediate preparation step, a diastereomer mixture preparation step, a chiral separation step and a chiral 3-substituted pyrrolidine derivative synthesis step. According to the invention, through catalytic asymmetric kinetic resolution, a mixture of two diastereoisomers is efficiently converted into a diastereoisomer with a certain single configuration, chiral separation is realized, a key intermediate is obtained with high yield, and a series of chiral 3-substituted pyrrolidine derivatives are synthesized. The whole reaction route is mild in reaction condition, simple and convenient to operate, high in resolution efficiency, high in atom economy, low in costand suitable for industrial scale production.
Preparation of novel azabicyclic amines and α7 nicotinic acetylcholine receptor activity of derived aryl amides
Walker, Daniel P.,Acker, Brad A.,Jacobsen, E. Jon,Wishka, Donn G.
, p. 247 - 257 (2008/09/18)
(Chemical Equation Presented) Three new azabicyclic amines, namely exo-3-amino-1-azabicyclo[3.2.1]octane, 3-amino-1-azabicyclo-[3.2.2]nonane and exo-6-amino-8-azabicyclo[3.2.1]octane, have been designed and prepared as isosteres of 3-aminoquinuclidine. Ar
QUINOLONE ANTIBACTERIAL AGENTS
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Page/Page column 88; 89; 122, (2010/02/12)
Compounds of formula (I) wherein A is formula (II), formula (III) or formula (IV), and B is formula (V), formula (VI), or formula (VII), can be used in a variety of applications including use as antibacterial agents.