173726-06-2

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 160666-92-2 (S)-2-benzoyloxypentan-3-one 
• 125948-63-2 (S)-2-hydroxypentan-⁽³⁾-one 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 207680-81-7 Benzoic acid (E)-(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1,3-dimethyl-2-oxo-hept-5-enyl ester 
• 1352831-83-4 (2S,4R,5R,6E)-2-benzoyloxy-5-diethylisopropylsilyloxy-4-methyloct-6-en-3-one 

Relevant academic research and scientific papers

Stereocontrolled total synthesis of (+)-concanamycin F: The strategic use of boron-mediated aldol reactions of chiral ketones

A highly stereocontrolled total synthesis of the 18-membered macrolide (+)-concanamycin F, a potent inhibitor of vacuolar ATPases, is described that proceeds in 5.8% yield over 26 steps. The three key fragments, C1-C13 vinyl iodide, C14-C22 vinyl stannane

Polyketide synthesis using the boron-mediated, anti-aldol reactions of lactate-derived ketones: Total synthesis of (-)-ACRL toxin IIIB

The boron-mediated, anti-selective, aldol reactions of ketone 2 (and related derivatives) proceed with high levels of asymmetric induction, diastereoselectivities of up to 200:1 in favour of the aldol adducts 4 are obtained with achiral aldehydes and reag