17375-67-6Relevant academic research and scientific papers
Cyclooxygenase inhibitory properties of nor -neolignans from Styrax pohlii
Bertanha, Camila S.,Braguine, Caio G.,Moraes, Ana C.G.,Gimenez, Valéria M.M.,Groppo, Milton,Silva, Márcio L.A.,Cunha, Wilson R.,Januário, Ana H.,Pauletti, Patrcia M.
, p. 2323 - 2329 (2012)
Chemical investigation of the n-hexane and EtOAc fractions of the ethanolic extract from Styrax pohlii (Styracaceae) aerial parts resulted in the isolation of the benzofuran nor-neolignan derivatives egonol (1), homoegonol (2), homoegonol gentiobioside (3), homoegonol glucoside (4) and egonol gentiobioside (5). This is the first report of compounds 1-5 in S. pohlii. Compounds 1-5, the acetyl derivatives 1a and 2a, the ethanolic extract (EE), the n-hexane fraction (HF) and EtOAc fraction (EF) were tested for their inhibitory activities against COX-1 and COX-2. The results showed that EE, HF, EF and compounds 1-5 and 1a-2a shown weak to moderate inhibition of COX-1 and COX-2. Among the assayed nor-neolignans, 4 gave a COX-1 inhibition of 35.7% at 30μM. Compound 5 displayed a COX-2 inhibition of 19.7% at 30μM.
NOVEL 2-PHENYLBENZOFURAN DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASE COMPRISING SAME AS ACTIVE INGREDIENT
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, (2016/12/01)
The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same
A convenient two-step synthesis of 2-arylbenzofurans
Duan, Xin-Fang,Feng, Jian-Xia,Zhang, Zhan-Bin
experimental part, p. 515 - 519 (2010/06/11)
A novel and convenient two-step synthesis of 2-arylbenzofurans is described which proceeds via a selective cross-pinacol-type coupling between a salicylaldehyde and an aromatic aldehyde, followed by an acid-promoted cyclization. One advantage of this method is that separation of the three possible pinacol products that can form during the cross-coupling is not necessary. This method is also applied to the synthesis of the 2-arylbenzofuran-containing natural product, homoegonol.
Total synthesis of ailanthoidol, egonol, and related analogues
Duan, Xin-Fang,Shen, Gang,Zhang, Zhan-Bin
experimental part, p. 1181 - 1187 (2010/06/12)
Efficient and general synthetic protocols were developed for the total synthesis of ailanthoidol, egonol, and some related analogues. The key transformations describe here involve a two-step construction of the benzofuran and a Sonogashira coupling, and proved to be convenient and effective, starting from readily available reagents.
