17379-38-3 Usage
Uses
Used in Organic Synthesis:
3-(TRIMETHYLSILYL)PYRIDINE-4-CARBONITRILE is used as a reagent for protecting reactive functional groups such as hydroxyl or amino groups during chemical reactions. The trimethylsilyl group provides a means to temporarily shield these groups, facilitating the synthesis of complex organic molecules without unwanted side reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(TRIMETHYLSILYL)PYRIDINE-4-CARBONITRILE is utilized for the synthesis of biologically active molecules. Its unique structure allows for the creation of compounds with potential therapeutic properties, contributing to the development of new drugs and medicinal agents.
Used in Materials Science:
3-(TRIMETHYLSILYL)PYRIDINE-4-CARBONITRILE is also used in the field of materials science for the construction of functional organic materials. Its structural features make it a candidate for the development of materials with specific properties, such as improved stability or reactivity, for various applications in technology and industry.
Check Digit Verification of cas no
The CAS Registry Mumber 17379-38-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,3,7 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17379-38:
(7*1)+(6*7)+(5*3)+(4*7)+(3*9)+(2*3)+(1*8)=133
133 % 10 = 3
So 17379-38-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2Si/c1-12(2,3)9-7-11-5-4-8(9)6-10/h4-5,7H,1-3H3
17379-38-3Relevant articles and documents
Transition-Metal-Free Cross-Coupling of Aryl and N-Heteroaryl Cyanides with Benzylic Zinc Reagents
Quinio, Pauline,Roman, Daniela Sustac,León, Thierry,William, Sharankini,Karaghiosoff, Konstantin,Knochel, Paul
supporting information, p. 4396 - 4399 (2015/09/15)
Functionalized 4-benzylated pyridines can be efficiently prepared by a transition-metal-free cross-coupling between various benzylic zinc chlorides and substituted 4-cyanopyridines in THF/DMPU under microwave irradiation (40 °C, 0.5-1.5 h). Selective benzylations on polycyano-aromatics have also been achieved under these mild conditions. We also report a novel oxidative nucleophilic substitution of a hydrogen on 1,3-dicyanobenzene using benzylic zinc reagents.
Synthesis of ortho-substituted cyanopyridines through lithio intermediate trapping
Cailly, Thomas,Fabis, Frédéric,Lema?tre, Stéphane,Bouillon, Alexandre,Rault, Sylvain
, p. 135 - 137 (2007/10/03)
Ortholithiation of 4-cyanopyridine using 2,2,6,6-tetramethylpiperidide (LiTMP) and trapping the lithio intermediate with electrophiles represents an efficient and straightforward access to ortho-substituted-4-cyanopyridines. The cyano group can be used as an ortho-directing group and allows the preparation of 3-halogeno-4-cyanopyridines. Reactivity of 2- and 3-cyanopyridines is also investigated and seems to give similar results.
