17380-22-2Relevant academic research and scientific papers
Decarboxylative/decarbonylative C3-acylation of indoles: Via photocatalysis: A simple and efficient route to 3-acylindoles
Shi, Qing,Li, Pinhua,Zhu, Xianjin,Wang, Lei
, p. 4916 - 4923 (2016/11/04)
A simple and efficient strategy for the preparation of 3-acylindoles via visible-light promoted C3-acylation of free (NH)- and N-substituted indoles with α-oxocarboxylic acids was developed. The reaction tolerates a wide range of functional groups, and the corresponding 3-acylindoles were obtained in high yields under mild conditions.
Regioselective Friedel-Crafts acylation of indoles catalysed by zinc oxide in an ionic liquid
Zhang, Li-Rong,Yi, Feng-Ping,Zou, Jian-Zhong,Zhang, Xuan,Wang, Zhen
, p. 600 - 602,3 (2020/09/16)
A facile method for the regioselective Friedel-Crafts acylation of indoles with acyl chlorides catalysed by zinc oxide in an ionic liquid medium has been developed. The corresponding 3-acylindoles were obtained in good to high yields under mild reaction conditions. Zinc oxide, which is easily available and requires no special handling procedures, is an efficient catalyst for acylation of indoles.
Mild and selective Ru-catalyzed formylation and Fe-catalyzed acylation of free (N-H) indoles using anilines as the carbonyl source
Wu, Wenliang,Su, Weiping
supporting information; experimental part, p. 11924 - 11927 (2011/09/19)
C3-selective formylation and acylation of free (N-H) indoles under mild conditions can be achieved by using Ru- and Fe-catalyzed oxidative coupling of free (N-H) indoles with anilines, respectively. Both processes are operationally simple, compatible with a variety of functional groups and generally provide the desired products in good yields. 13C-labeling experiments unambiguously established that the carbonylic carbon in the formylation products originated from methyl group of N-methyl aniline.
