17382-10-4Relevant academic research and scientific papers
Synthesis of Functionalized Tetrahydropyridines by SnCl4-Mediated [4+2] Cycloaddition between Donor–Acceptor Cyclobutanes and Nitriles
Tong, David,Wu, Jackie,Bazinski, Nathan,Koo, Donghyun,Vemula, Naresh,Pagenkopf, Brian L.
supporting information, p. 15244 - 15247 (2019/11/14)
Cycloadditions of strained carbocycles promoted by Lewis acids are powerful methods to construct heterocyclic frameworks. In fact, the formal [3+2] cycloadditions of donor–acceptor (DA) cyclopropanes with nitriles has seen particular success in synthesis. In this work, we report on the first [4+2] cycloaddition of nitriles with DA cyclobutanes by Lewis acid activation. Tetrahydropyridine derivatives were obtained in up to 91 % yield from various aryl-activated cyclobutane diesters and aliphatic or aromatic nitriles.
DOPAMINE D3 RECEPTOR ANTAGONISTS COMPOUNDS
-
Page/Page column 326, (2016/05/19)
The disclosure is directed to novel dopamine D3 receptor antagonists, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, including treating drug dependency and psychosis.
Formal [4 + 2] cycloaddition of donor-acceptor cyclobutanes and aldehydes: Stereoselective access to substituted tetrahydropyrans
Parsons, Andrew T.,Johnson, Jeffrey S.
supporting information; experimental part, p. 14202 - 14203 (2010/02/16)
(Chemical Equation Presented) A highly diastereoselective synthesis of 2,6-cis-disubstituted tetrahydropyrans (THPs) via Lewis acid-catalyzed formal [4 + 2] cycloaddition of donor-acceptor cyclobutanes and aldehydes has been developed. THP products are fo
