173837-67-7

Basic information

• Product Name: (R)-2-(2,4-difluorophenyl)-3-propionyloxy-1,2-propanediol
• Synonyms: (R)-2-(2,4-difluorophenyl)-3-propionyloxy-1,2-propanediol
• CAS NO: 173837-67-7
• Molecular Weight: 260.238
• Mol File: 173837-67-7.mol

Chemical Properties

• CAS DataBase Reference: (R)-2-(2,4-difluorophenyl)-3-propionyloxy-1,2-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2,4-difluorophenyl)-3-propionyloxy-1,2-propanediol(173837-67-7)
• EPA Substance Registry System: (R)-2-(2,4-difluorophenyl)-3-propionyloxy-1,2-propanediol(173837-67-7)

Safety Data

• Hazardous Substances Data: 173837-67-7(Hazardous Substances Data)

Upstream product

• 173837-46-2 1,3-dipropionyloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173838-01-2 1,3-dipropionyloxyacetone 
• 348-57-2 2,4-difluorobromobenzene 
• 173837-65-5 2-(2,4-difluorophenyl)-1,2,3-propanetriol 
• 173837-47-3 2-(2,4-difluorophenyl)-1,3-di-n-pentanoyloxy-2-propanol 
• 173837-48-4 1,3-di-n-butyryloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-49-5 1,3-diisobutyryloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-45-1 1,3-diacetoxy-2-(2,4-difluorophenyl)-2-propanol 

Relevant articles and documents

A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.

Enzymatically enantioselective hydrolysis of prochiral 1,3-diacyloxyglycerol derivatives.

An enzymatically enantioselective ester hydrolysis of prochiral 1,3-diacyloxy-2-substituted-2-propanol to chiral 1-acyloxy-2,3-propanediol was studied. The (R)-monoester was prepared by selection of a suitable lipase and alkyl chain length of the substrate diester. Lipase D from Rhizopus delemer gave (R)-1-isobutyryloxy-2-(2,4-difluorophenyl)-2,3-propanediol with 97%ee and 87% yield at 15 degrees C and pH 5.5. The (R)-monoester is a key intermediate of azole antifungal agents.

Triazole derivatives

The present invention relates to a novel glycerol derivative and a process for preparing the same, and a process for preparing a triazole derivative. According to the present invention, an optical active 2-arylglycerol derivative which is a novel and useful as a synthetic intermediate of medicament can be provided and furthermore, (R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)-propane-1,2-diol which is useful as an antifungal agent can be prepared.