173837-47-3

Upstream product

• 348-57-2 2,4-difluorobromobenzene 
• 347173-03-9 2-oxopropane-1,3-diyl dipentanoate 
• 2082-59-9 pentanoic anhydride 
• 173837-65-5 2-(2,4-difluorophenyl)-1,2,3-propanetriol 
• 173837-48-4 1,3-di-n-butyryloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-49-5 1,3-diisobutyryloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-46-2 1,3-dipropionyloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-45-1 1,3-diacetoxy-2-(2,4-difluorophenyl)-2-propanol 

Downstream Products

• 173837-69-9 (R)-2-(2,4-difluorophenyl)-3-n-pentanoyloxy-1,2-propanediol 
• 173837-48-4 1,3-di-n-butyryloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-46-2 1,3-dipropionyloxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-68-8 (R)-2-(2,4-difluorophenyl)-3-n-butyryloxy-1,2-propanediol 
• 173837-45-1 1,3-diacetoxy-2-(2,4-difluorophenyl)-2-propanol 
• 173837-67-7 (R)-2-(2,4-difluorophenyl)-3-propionyloxy-1,2-propanediol 
• 173837-62-2 (R)-1-acetyloxy-2-(2,4-difluorophenyl)-2,3-propanediol 
• 173837-65-5 2-(2,4-difluorophenyl)-1,2,3-propanetriol 

Relevant academic research and scientific papers

Enzymatically enantioselective hydrolysis of prochiral 1,3-diacyloxyglycerol derivatives.

An enzymatically enantioselective ester hydrolysis of prochiral 1,3-diacyloxy-2-substituted-2-propanol to chiral 1-acyloxy-2,3-propanediol was studied. The (R)-monoester was prepared by selection of a suitable lipase and alkyl chain length of the substrate diester. Lipase D from Rhizopus delemer gave (R)-1-isobutyryloxy-2-(2,4-difluorophenyl)-2,3-propanediol with 97%ee and 87% yield at 15 degrees C and pH 5.5. The (R)-monoester is a key intermediate of azole antifungal agents.

A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.