173841-91-3Relevant academic research and scientific papers
Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes
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Page/Page column 9, (2012/06/30)
There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula I comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The invention may further provid
Substituted 1,3-oxathiolanes with antiviral properties
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Example 14, (2008/06/13)
This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R1is hydrogen, and R2is cytosine or 5-fluorocytosine; and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.
Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
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, (2008/06/13)
This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes or pharmaceutically acceptable salts and esters thereof, of the formula: STR1 wherein X is S, S=O, or SO2 ; Y is O, S, S=O, or SO2 ; R1
Synthesis of Optically Active 2',3'-Dideoxy-3'-oxa-4'-thio-ribonucleoside Analogues by Transposition of a Leaving Group on Chiral Oxathiolanes via a Reductive-oxidative Process
Wang, Wei,Jin, Haolun,Mansour, Tarek S.
, p. 4739 - 4742 (2007/10/02)
The synthesis of chiral nucleoside analogues with a unique structural feature is reported.The strategy is based on a reductive-oxidative process to complete the transposition of the leaving group in chiral oxathiolanes with known configuration.
