143338-44-7Relevant articles and documents
Asymmetric synthesis of optically active 1,3-oxathiolane nucleoside analogues
Caputo, Romualdo,Guaragna, Annalisa,Palumbo, Giovanni,Pedatella, Silvana
, p. 1739 - 1745 (1998)
A ready asymmetric synthesis of 3'-oxa-4'-thionucleosides has been accomplished in three main steps from benzoyloxyethanal. The synthesis is characterized by high overall yield and appreciable enantiomeric excesses. It represents a general synthetic scheme to prepare a wide range of heterosubstituted sulfur-containing nucleoside analogues.
Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes
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, (2010/06/19)
There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula I comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The invention may further provide for the esterification and racemization of the by-product of the enzymatic reaction. In this manner, 2(R)-(benzoyloxymethyl)-1,3-oxathiolane is prepared as a useful intermediate for manufacture of the anti-HIV drug Apricitabine.
Substituted 1,3-oxathiolanes with antiviral properties
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Example 2, (2008/06/13)
This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R1is hydrogen, and R2is cytosine or 5-fluorocytosine; and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.