17385-01-2Relevant academic research and scientific papers
PROCESS FOR PREPARING A PROPIOLIC ACID OR A DERIVATIVE THEREOF
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Paragraph 0147 - 0151; 0155, (2014/02/15)
The invention relates to a process for preparing a propiolic acid or a derivative thereof by reacting a terminal alkyne with carbon dioxide, which comprises performing the reaction in the presence of a base and a copper complex, especially a copper (I) complex having at least one ligand, at least one of the ligands of the copper complex being selected from monodentate ligands which have an aminic or iminic nitrogen atom capable of coordination with copper, and polydentate ligands having at least two atoms or atom groups which are capable of simultaneous coordination with copper and are selected from nitrogen, oxygen, sulfur, phosphorus and carbene carbon.
Synthesis of propiolic acids via copper-catalyzed insertion of carbon dioxide into the C-H bond of terminal alkynes
Goossen, Lukas J.,Rodriguez, Nuria,Manjolinho, Filipe,Lange, Paul P.
supporting information; experimental part, p. 2913 - 2917 (2011/02/22)
A highly effective copper catalyst has been developed that promotes the insertion of carbon dioxide into the C-H bond of terminal alkynes under unprecedentedly mild conditions. For the first time, propiolic acids can thus be synthesized in excellent yields from alkynes and carbon dioxide in the presence of the mild base cesium carbonate. The catalyst, (4,7-diphenyl-1,10- phenanthroline)bis[tris(4-fluorophenyl)phosphine]copper(I) nitrate, is easy accessible and relatively stable against air and water. Copyright
