17386-89-9

Basic information

• Product Name: 1-(3,4-Dihydroxyphenyl)butan-1-one
• Synonyms: 1-(3,4-Dihydroxyphenyl)butan-1-one;3’,4’-Dihydroxy-1-phenyl-2-butanone;1-(3,4-Dihydroxyphenyl)-1-butanone;3',4'-Dihydroxybutyrophenone;4-Butyroylpyrocatechol
• CAS NO: 17386-89-9
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2005
• Product Categories: Aromatics
• Mol File: 17386-89-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 381.1°Cat760mmHg
• Flash Point: 198.4°C
• Appearance: /
• Density: 1.194g/cm³
• Vapor Pressure: 2.38E-06mmHg at 25°C
• Refractive Index: 1.567
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 1-(3,4-Dihydroxyphenyl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-Dihydroxyphenyl)butan-1-one(17386-89-9)
• EPA Substance Registry System: 1-(3,4-Dihydroxyphenyl)butan-1-one(17386-89-9)

Safety Data

• Hazardous Substances Data: 17386-89-9(Hazardous Substances Data)

Usage

Chemical Properties

Grey Solid

Uses

3’,4’-Dihydroxy-1-phenyl-2-butanone (cas# 17386-89-9) is a compound useful in organic synthesis.

InChI:InChI=1/C10H12O3/c1-2-3-8(11)7-4-5-9(12)10(13)6-7/h4-6,12-13H,2-3H2,1H3

Upstream product

• 120-80-9 benzene-1,2-diol 
• 98-95-3 nitrobenzene 
• 141-75-3 butyryl chloride 
• 107-92-6 butyric acid 
• 90-05-1 2-methoxy-phenol 
• 4112-92-9 1-butyryloxy-2-methoxy-benzene 

Downstream Products

• 29668-47-1 1-(2,3-dihydro-1,4-benzodioxin-6-yl)butan-1-one 
• 54419-21-5 1-(3,4-dimethoxyphenyl)butan-1-one 
• 91970-65-9 4-butyryl-2-hydroxy-1-methoxybenzene 
• 64142-23-0 4-butyryl-1-hydroxy-2-methoxybenzene 
• 2525-05-5 1,2-dihydroxy-4-butylbenzene 
• 25527-85-9 1-(3,4-Dihydroxyphenyl)-n-butanol 

Relevant articles and documents

A convenient synthetic approach to dioncoquinone B and related compounds

A total synthesis of dioncoquinone B and related compounds, including ancistroquinones B, C and malvon A, is presented. The strategy is based on available reagents and can be used as a preparative synthesis of a number of natural and synthetic biologically active (3-alkyl)-2,7,8-di(tri)methoxy(hydroxy)-1,4-naphthoquinones.

The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors

Some pyrogallol and catechol derivatives were synthesized, and their urease inhibitory activity was evaluated by using acetohydroxamic acid (AHA), a well known Helicobacter pylori urease inhibitor, as positive control. The assay results indicate that many compounds have showed potential inhibitory activity against H. pylori urease. 4-(4-Hydroxyphenethyl)phen-1,2-diol (2a) was found to be the most potent urease inhibitor with IC50s of 1.5 ± 0.2 μM for extracted fraction and 4.2 ± 0.3 μM for intact cell, at least 10 times and 20 times lower than those of AHA (IC50 of 17.2 ± 0.9 μM, 100.6 ± 13 μM), respectively. This finding indicate that 2a would be a potential urease inhibitor deserves further research. Molecular dockings of 2a into H. pylori urease active site were performed for understanding the good activity observed.