173933-40-9Relevant academic research and scientific papers
Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives
Wei, Xiaonan,Yang, Yaxing,Ge, Jiangfeng,Lin, Xue,Liu, Dandan,Wang, Shuxiang,Zhang, Jinchao,Zhou, Guoqiang,Li, Shenghui
, (2019/10/29)
Thirteen novel palladium(II) complexes of the general formula [Pd(bipy)(O,O′-dkt)](PF6), (where bipy is 2,2′-bipyridine and O,O′-dkt is β-diketonate ligand hispolon or its derivative) have been prepared through a metal-ligand coordination metho
Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor
Hotsumi, Mayumi,Tajiri, Misato,Nikaido, Yuri,Sato, Taki,Makabe, Koki,Konno, Hiroyuki
supporting information, p. 2157 - 2161 (2019/07/03)
A structure activity relationship study of curcumin analogues for the inhibition of amyloid β aggregation is described. Optimization of the o-phenol and olefin spacer resulted in the identification of the C5-monoketone type curcumin analogue AY1319, which
Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor
Endo, Hitoshi,Nikaido, Yuri,Nakadate, Mamiko,Ise, Satomi,Konno, Hiroyuki
, p. 5621 - 5626 (2015/01/08)
Inhibition of the amyloid β aggregation process could possibly prevent the onset of Alzheimer's disease. In this article, we report a structure-activity relationship study of curcumin analogues for anti amyloid β aggregation activity. Compound 7, the ideal amyloid β aggregation inhibitor in vitro among synthesized curcumin analogues, has not only potent anti amyloid β aggregation effects, but also water solubility more than 160 times that of curcumin. In addition, new approaches to improve water solubility of curcumin-type compounds are proposed.
Structural analogues of homoeriodictyol as flavor modifiers. Part III: Short chain gingerdione derivatives
Ley, Jakob P.,Paetz, Susanne,Blings, Maria,Hoffmann-Luecke, Petra,Bertram, Heinz-Juergen,Krammer, Gerhard E.
experimental part, p. 6656 - 6664 (2010/04/06)
In order to find new flavor modifiers, various short chain gingerdione derivatives were synthesized as structural analogues of the known bitter masker homoeriodictyol and evaluated by a sensory panel for masking and sweetness enhancing activities. 1-(4-Hy
Synthesis and antioxidant activity of hispolon, a yellow pigment from Inonotus hispidius
Venkateswarlu,Ramachandra,Sethuramu,Subbaraju, Gottumukkala V.
, p. 875 - 877 (2007/10/03)
Hispolon 5 has been synthesised from veratraldehyde 1, in four steps, with an overall yield of 23%. The spectral data of synthetic 5 are in agreement with those of natural 5. Hispolon shows strong antioxidant and weak antibacterial activities.
