443308-31-4Relevant academic research and scientific papers
Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives
Wei, Xiaonan,Yang, Yaxing,Ge, Jiangfeng,Lin, Xue,Liu, Dandan,Wang, Shuxiang,Zhang, Jinchao,Zhou, Guoqiang,Li, Shenghui
, (2019/10/29)
Thirteen novel palladium(II) complexes of the general formula [Pd(bipy)(O,O′-dkt)](PF6), (where bipy is 2,2′-bipyridine and O,O′-dkt is β-diketonate ligand hispolon or its derivative) have been prepared through a metal-ligand coordination metho
Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents
Lin, Li,Shi, Qian,Nyarko, Alexander K.,Bastow, Kenneth F.,Wu, Chin-Chung,Su, Ching-Yuan,Shih, Charles C.-Y.,Lee, Kuo-Hsiung
, p. 3963 - 3972 (2007/10/03)
In a continuing study of curcumin analogues as potential drug candidates to treat prostate cancer at both androgen-dependent and androgen-refractory stages, we designed and synthesized over 40 new analogues classified into four series: monophenyl analogues (series A), heterocycle-containing analogues (series B), analogues bearing various substituents on the phenyl rings (series C), and analogues with various linkers (series D). These new compounds were tested for cytotoxicity against two human prostate cancer cell lines, androgen-dependent LNCaP and androgen-independent PC-3. Antiandrogenic activity was also evaluated in LNCaP cells and PC-3 cells transfected with wild-type androgen receptor. Ten compounds possessed potent cytotoxicity against both LNCaP and PC-3 cells, seven only against LNCaP, and one solely against PC-3. This study established an advanced structure-activity relationship (SAR), and these correlations will guide the further design of new curcumin analogues with better anti-prostate cancer activity.
Synthesis and antioxidant activity of hispolon, a yellow pigment from Inonotus hispidius
Venkateswarlu,Ramachandra,Sethuramu,Subbaraju, Gottumukkala V.
, p. 875 - 877 (2007/10/03)
Hispolon 5 has been synthesised from veratraldehyde 1, in four steps, with an overall yield of 23%. The spectral data of synthetic 5 are in agreement with those of natural 5. Hispolon shows strong antioxidant and weak antibacterial activities.
