17396-35-9

Usage

Uses

Used in Flavor and Fragrance Industry:
1,1-Dioxo-tetrahydro-thiopyran-4-one is utilized as a flavoring agent to impart fruity and sulfurous notes to a variety of products. Its strong, characteristic odor makes it a valuable addition in the creation of complex and nuanced scents and tastes.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 1,1-Dioxo-tetrahydro-thiopyran-4-one serves as a key intermediate in the synthesis of various drugs. Its unique chemical structure allows for the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical sector, 1,1-Dioxo-tetrahydro-thiopyran-4-one is employed in the production of pesticides and other agricultural chemicals. Its reactivity and structural properties make it a useful component in the formulation of effective and targeted agrochemical products.
It is crucial to handle 1,1-Dioxo-tetrahydro-thiopyran-4-one with caution due to its potential hazards if not managed properly, ensuring safety in its applications across different industries.

InChI:InChI=1/C5H8O3S/c6-5-1-3-9(7,8)4-2-5/h1-4H2

Upstream product

• 1072-72-6 Tetrahydrothiopyran-4-one 
• 39557-51-2 diallyl 3,3'-thiodipropanoate 
• 408314-20-5 3,5-dibromo-1,1-dioxo-tetrahydro-1λ⁶-thiopyran-4-one 
• 139-33-3 edetate disodium 
• 1003-41-4 4H-thiopyran-4-one 
• 126573-38-4 tetrahydrothiopyran-4-one-3-carboxylic acid allyl ester 
• 111-17-1 4-thiaheptane-1,7-dioic acid 
• 4131-74-2 Dimethyl 3,3'-thiodipropionate 
• 4160-61-6 3-methoxycarbonyltetrahydropyran-4-one 
• 126573-42-0 3-allyloxycarbonyl-4-thianone-1,1-dioxide 
• 17396-38-2 4H-Thiopyran-4-one 1,1-dioxide 

Downstream Products

• 16841-46-6 3,6-dihydro-2H-thiopyran 1,1-dioxide 
• 194152-05-1 4-hydroxytetrahydro-2H-thiopyrane 1,1-dioxide 
• 98862-95-4 5-benzyl-1,3,4,5-tetrahydro-thiopyrano[4,3-b]indole 2,2-dioxide 
• 100104-82-3 5-benzyl-2,2-dioxo-2,3,4,5-tetrahydro-1H-2λ⁶-thiopyrano[4,3-b]indole-8-carboxylic acid ethyl ester 
• 83319-96-4 3,5-Bis-[1-(4-tert-butyl-phenyl)-meth-(Z)-ylidene]-1,1-dioxo-tetrahydro-1λ⁶-thiopyran-4-one 
• 61448-83-7 (3Z,5Z)‐3,5‐bis({[3‐(trifluoromethyl)phenyl]methylidene})‐1λ6‐thiane‐1,1,4‐trione 
• 70343-39-4 (3Z,5Z)-3,5-bis[(4-methylphenyl)methylene]tetrahydro-4H-thiopyran-4-one 1,1-dioxide 
• 70332-85-3 tetrahydro-3,5-bis-(phenylmethylene)-4H-thiopyran-4-one-1,1-dioxide 
• 87943-00-8 1,1-Dioxo-4-phenylethynyl-hexahydro-1λ⁶-thiopyran-4-ol 
• 4988-33-4 pentamethylene sulfone 
• 474843-59-9 2-amino-6,6-dioxo-4,5,6,7-tetrahydro-6-thieno[2,3-c]thiopyran-3-carboxylic acid ethyl ester 
• 17396-38-2 4H-Thiopyran-4-one 1,1-dioxide 
• 87955-41-7 4-Phenylethynyl-3,6-dihydro-2H-thiopyran 1,1-dioxide 
• 87955-59-7 6-Phenylethynyl-7-oxa-3-thia-bicyclo[4.1.0]heptane 3,3-dioxide 

Relevant academic research and scientific papers

COMPOSITES, METHODS AND USES THEREOF

The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.

Cobalt Single-Atom-Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity

The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long-standing pursuit in chemical synthesis. A vertically structured, cobalt single atom-intercalated molybdenum disulfide catalyst (Co1-in-MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single-atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal–substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide-bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high-value, multifunctional sulfones and late-stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom-intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions.

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Synthesis method of tetrahydrothiapyran-4-one 1,1-dioxide

The invention discloses a preparation method of tetrahydrothiapyran-4-one 1,1-dioxide, and belongs to the technical field of battery electrolytic solutions. The preparation method comprises the following steps: adding pyridine into an ethyl acetate solution of tetrahydrothiapyran-4-one under the condition of -5 to 0 DEG C, heating to 20 to 30 DEG C, adding peracetic acid into the ethyl acetate solution under a stirring condition, continuously stirring for 1 to 2 hours, quenching with water, cooling to -10 to 0 DEG C, filtering, collecting precipitates, washing with ethyl acetate, and drying under reduced pressure to obtain tetrahydrothiapyran-4-one 1,1-dioxide. The synthesis method is simple, and the obtained methanedisulfonyl fluoride is high in yield, high in purity and less in moisture.

Multigram scale synthesis of 3,4- and 3,6-dihydro-2H-thiopyran 1,1-dioxides and features of their NMR spectral behavior

A new four-step synthesis of 3,4- and 3,6-dihydro-2H-thiopran-1,1-dioxides from dihydro-2H-thiopyran-3(4H)-one is reported. The title compounds are synthesized starting with oxidation of the ketone with a 30% aqueous solution of hydrogen peroxide in a mixture of AcOH-Ac2O. The keto group is then reduced by sodium borohydride followed by mesylation and elimination of methanesulfonic acid under basic conditions (pyridine for 3,4-isomer and aqueous NaOH for 3,6-isomer). This sequence is simpler, than previously known methods, uses cheaper and more readily available reagents, and leads to 2H-thiopran-1,1-dioxides on multigram scale with 64% and 74% total yields, respectively. The structure and purity of the compounds were confirmed by 2D NMR and GCMS methods. The proposed method expands the means to access functionalized cyclic sulfones as building blocks in the synthesis of combinatorial libraries of new biologically active compounds.

Synthesis and characterization of sulfide, sulfoxide and sulfone derivatives of thiopyran: antimicrobial evaluation

Abstract: A series of thiopyran derivatives and their oxidized analogous forms were synthesized and characterized by FT-IR, 1H, 13C, 31P NMR and mass spectroscopy techniques. The antibacterial and antifungal activities of these synthesized materials were evaluated against Staphylococcus aureus and Bacillus subtilis, as Gram-positive bacteria, and Escherichia coli and Pseudomonas aeruginosa, as Gram-negative bacteria, as well as the fungus Candida albicans. The results revealed that thiopyran S,S-dioxides are the most effective against all the bacteria studied in this work. Furthermore, thiopyran S-oxides showed excellent antifungal activity against Candida albicans.

Polyoxomolybdate-Calix[4]arene Hybrid: A Catalyst for Sulfoxidation Reactions with Hydrogen Peroxide

An easily accessible polyoxomolybdate-calix[4]arene hybrid 1 has been synthesized and applied as a heterogeneous catalyst in the sulfoxidation of thioethers to sulfoxides and to sulfones under strictly stoichiometric amounts of 30% H2O2 in CH3CN as the solvent. This study represents the first promising example of successful employment of calixarenes-polyoxometalate (POM) hybrid materials in the area of catalytic oxidations.

HETEROCYCLIC COMPOUND

The present invention provides to a compound having melanin-concentrating hormone receptor antagonistic action and low toxicity, and useful as a agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound re

THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS

The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer

Observed and calculated 1Hand 13C chemical shifts induced by the in situ oxidation ofmodel sulfides to sulfoxides and sulfones

A series of model sulfides was oxidized in the NMR sample tube to sulfoxides and sulfones by the stepwise addition of meta-chloroperbenzoic acid in deuterochloroform. Various methods of quantum chemical calculations have been tested to reproduce the observed 1H and 13C chemical shifts of the starting sulfides and their oxidation products. It has been shown that the determination of the energy-minimized conformation is a very important condition for obtaining realistic data in the subsequent calculation of the NMR chemical shifts. The correlation between calculated and observed chemical shifts is very good for carbon atoms (even for the 'cheap' DFT B3LYP/6-31G* method) and somewhat less satisfactory for hydrogen atoms. The calculated chemical shifts induced by oxidation (the δd values) agree even better with the experimental values and can also be used to determine the oxidation state of the sulfur atom (-S-, -SO-, -SO2 -). Copyright