61448-83-7

Upstream product

• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 17396-35-9 1,1-dioxotetrahydrothiopyran-4-one 
• 61448-84-8 (3Z,5Z)‐3,5‐bis({[3‐(trifluoromethyl)phenyl]methylidene})thian‐4‐one 
• 1072-72-6 Tetrahydrothiopyran-4-one 
• 7722-84-1 dihydrogen peroxide 

Downstream Products

• 70355-59-8 2-isopropyl-7-((Z)-3-trifluoromethyl-benzylidene)-3-(3-trifluoromethyl-phenyl)-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 
• 83319-92-0 1-isopropyl-7-((Z)-3-trifluoromethyl-benzylidene)-3-(3-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 
• 83319-78-2 2-Prop-2-ynyl-3-(3-trifluoromethyl-phenyl)-7-[1-(3-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 
• 61448-74-6 3-(3-Trifluoromethyl-phenyl)-7-[1-(3-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 
• 61448-68-8 2-propyl-7-(3-trifluoromethyl-benzylidene)-3-(3-trifluoromethyl-phenyl)-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 
• 61448-75-7 2-acetyl-2,3,3a,4,6,7-hexahydro-3-[3-(trifluoromethyl)phenyl]-7-{[3-(trifluoromethyl)phenyl]methylene}thiopyranol[4,3-c]pyrazole 5,5-dioxide 
• 83319-85-1 2-acetyl-2,3,3a,4,6,7-hexahydro-3-[3-(trifluoromethyl)phenyl]-7-{[3-(trifluoromethyl)phenyl]methyl}thiopyrano[4,3-c]pyrazole 5,5-dioxide 
• 83319-77-1 2-Methyl-3-(3-trifluoromethyl-phenyl)-7-[1-(3-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 
• 61448-68-8 2-Propyl-3-(3-trifluoromethyl-phenyl)-7-[1-(3-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 

Relevant academic research and scientific papers

Antimalarial activity of 2,6-dibenzylidenecyclohexanone derivatives

Malaria remains one of the deadliest infectious diseases worldwide and continues to infect hundreds of millions of individuals each year. Here we report the discovery and derivatization of a series of 2,6-dibenzylidenecyclohexanones targeting the chloroquine-sensitive 3D7 strain of Plasmodium falciparum. While the initial lead compound displayed significant toxicity in a human cell proliferation assay, we were able to identify a derivative with no detectable toxicity and sub-micromolar potency.

Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues

A series of novel hexahydrothiopyrano[4,3-c]pyrazoles and related analogues were prepared and tested for antiinflammatory activity by using the mouse active Arthus reaction and the delayed hypersensitivity skin reaction in guinea pigs as primary screens.

Substituted pyrano[4,3-c]pyrazoles, compositions containing same, and method of use

2,4,6,7-Tetrahydropyrano[4,3-c]pyrazoles are provided having the formula STR1 wherein Z is O, S, SO or SO2 ; R is H, halo, lower alkyl, lower alkoxy, lower alkanoyl, aroyl, cyano or CF3 ; and R' is H, lower alkyl, aryl-lower alkyl, a