173975-58-1

Upstream product

• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 173975-57-0 (2S,4S)-4-(2,6-Dichloro-phenyl)-2-phenyl-[1,3]dioxane 
• 173975-56-9 (2S,4S)-4-(2,6-Dichloro-phenyl)-2-pentyl-[1,3]dioxane 
• 173975-55-8 (2S,4S)-2-Cyclohexyl-4-(2,6-dichloro-phenyl)-[1,3]dioxane 

Relevant academic research and scientific papers

Chiral primary amine catalyzed asymmetric direct cross-aldol reaction of acetaldehyde

The first primary aminocatalytic direct cross-aldol reaction of acetaldehyde is presented. Among the various vicinal diamines screened, the L-tert-leucine derivative 1c in conjunction with (H4SiW 12O40)0.25 was identified as the optimal catalyst; good catalytic activity (up to 99% yield in 4 h), and high enantioselectivities (up to 92% ee) were achieved for a range of donors, including aromatic aldehydes and isatin derivatives. Aqueous acetaldehyde solution and paraldehyde can be conveniently applied in this system.

Asymmetric Additions to Dichlorophenyldioxane, A New Chiral Acetal

4-(2,6-Dichlorophenyl)-1,3-dioxanes have been reacted with weak nucleophiles and TiCl4 to give benzyl ethers with high selectivity.The major products are consistent with an SN2-like mechanism.The benzyl ether is removed in one step using Li/NH3 to give non-racemic secondary alcohols.